MSRA Products
(Methionine Sulfoxide Reductase A (MSRA))
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This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
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Latest Publications for our MSRA products
: "Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation." in: Antioxidants & redox signaling, Vol. 24, Issue 5, pp. 263-79, (2016) (PubMed).: "Protein oxidation and degradation caused by particulate matter." in: Scientific reports, Vol. 6, pp. 33727, (2016) (PubMed).
: "Dysfunction of methionine sulfoxide reductases to repair damaged proteins by nickel nanoparticles." in: Chemico-biological interactions, Vol. 236, pp. 82-9, (2015) (PubMed).
: "Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A." in: Cell death & disease, Vol. 5, pp. e1490, (2014) (PubMed).
: "Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 43, pp. 18628-33, (2010) (PubMed).
: "HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase." in: The Biochemical journal, Vol. 346 Pt 2, pp. 305-11, (2000) (PubMed).
Synonyms and alternative names related to MSRA
methionine sulfoxide reductase A (Msra), methionine sulfoxide reductase A (MSRA), 2310045J23Rik, 6530413P12Rik, MSR-A, PMSRProtein level used designations for MSRA
- PMSR
- mitochondrial peptide methionine sulfoxide reductase
- peptide Met(O) reductase
- peptide methionine sulfoxide reductase
- peptide-methionine (S)-S-oxide reductase
- protein-methionine-S-oxide reductase
- cytosolic methionine-S-sulfoxide reductase
- peptide met (O) reductase
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