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MSK1 Products

(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Categories

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto- oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro- inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti- inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.

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Featured MSK1 Categories

MSK1 Antibodies

High quality antibodies with extensive validation data.

MSK1 ELISA Kits

Reliable ELISA kits for a wide range of species.

MSK1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MSK1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7168188
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (4)
Cat. No. ABIN522729
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7270039
Quantity 100 μL
Datasheet Datasheet

Recommended MSK1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380644
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380780
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380308
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended MSK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
Cat. No. ABIN1318830
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318832
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318834
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our MSK1 products

Zhang, Guo, Zhang, Liu, Dong: "Aloe emodin suppresses EGF‑induced neoplastic cell transformation by inhibiting the ERK/MSK1 and AKT/GSK3β signaling pathways." in: Molecular medicine reports, Vol. 18, Issue 6, pp. 5215-5220, (2019) (PubMed).

McCoy, Campbell, Deak, Bloomberg, Arthur: "MSK1 activity is controlled by multiple phosphorylation sites." in: The Biochemical journal, Vol. 387, Issue Pt 2, pp. 507-17, (2005) (PubMed).

Roux, Blenis: "ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions." in: Microbiology and molecular biology reviews : MMBR, Vol. 68, Issue 2, pp. 320-44, (2004) (PubMed).

Zhang, Cho, Petersen, Zhu, Dong: "Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1." in: Carcinogenesis, Vol. 25, Issue 7, pp. 1165-75, (2004) (PubMed).

Abécassis, Rogier, Vazquez, Atfi, Bourgeade: "Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways." in: The Journal of biological chemistry, Vol. 279, Issue 29, pp. 30474-9, (2004) (PubMed).

Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).

Wiggin, Soloaga, Foster, Murray-Tait, Cohen, Arthur: "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts." in: Molecular and cellular biology, Vol. 22, Issue 8, pp. 2871-81, (2002) (PubMed).

Jiang, Yu, Tu, Zhao, Zhang, Zhao: "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping." in: Cytogenetics and cell genetics, Vol. 87, Issue 3-4, pp. 261-2, (2000) (PubMed).

New, Zhao, Li, Bassett, Feng, Ludwig, Padova, Gram, Han: "Cloning and characterization of RLPK, a novel RSK-related protein kinase." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 1026-32, (1999) (PubMed).

Synonyms and alternative names related to MSK1

ribosomal protein S6 kinase A5 (RPS6KA5), ribosomal protein S6 kinase, polypeptide 5 (Rps6ka5), ribosomal protein S6 kinase A5 (Rps6ka5), 3110005L17Rik, 6330404E13Rik, AI854034, MSK1, Msk1, MSPK1, RLPK

Protein level used designations for MSK1

  • 90 kDa ribosomal protein S6 kinase 5
  • RSK-like protein kinase
  • RSKL
  • S6K-alpha-5
  • nuclear mitogen- and stress-activated protein kinase 1
  • ribosomal protein S6 kinase alpha-5
  • mitogen- and stress-activated protein kinase-1
  • ribosomal protein S6 kinase, polypeptide 5
  • RLSK
  • mitogen and stress-activated protein kinase 1
  • ribosomal protein S6 kinase, 90kDa, polypeptide 5
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