MSH6 Products
(MutS Homolog 6 (E. Coli) (MSH6))
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This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer. [provided by RefSeq, Jul 2008].
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Featured MSH6 Categories
MSH6 Antibodies
High quality antibodies with extensive validation data.
MSH6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MSH6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, ICC, FACS
Validations
- (1)
- (7)
Cat. No.
ABIN969293
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, ICC, FACS
Validations
- (8)
Cat. No.
ABIN7193706
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS
Validations
- (6)
Cat. No.
ABIN7193700
Quantity
100 μL
Datasheet
Datasheet
Recommended MSH6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
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Cat. No.
ABIN1311444
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093948
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134489
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MSH6 products
: "Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer." in: Cold Spring Harbor molecular case studies, Vol. 3, Issue 5, (2017) (PubMed).: "DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication." in: Journal of virology, Vol. 85, Issue 23, pp. 12241-53, (2011) (PubMed).
: "Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair." in: Nucleic acids research, Vol. 39, Issue 6, pp. 2130-43, (2011) (PubMed).
: "Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90." in: The Journal of experimental medicine, Vol. 207, Issue 12, pp. 2751-65, (2010) (PubMed).
: "Modulation of mismatch repair and genomic stability by miR-155. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 15, pp. 6982-7, (2010) (PubMed).
: "Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." in: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).
: "Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion." in: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 34531-7, (2009) (PubMed).
: "Germ-line mutations in mismatch repair genes associated with prostate cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2460-7, (2009) (PubMed).
: "Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA)." in: Nucleic acids research, Vol. 36, Issue 1, pp. 67-75, (2008) (PubMed).
: "Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding." in: The Journal of biological chemistry, Vol. 283, Issue 46, pp. 31641-8, (2008) (PubMed).
Synonyms and alternative names related to MSH6
mutS homolog 6 (MSH6), mutS homolog 6 (E. coli) (msh6), mutS homolog 6 (msh6), mutS homolog 6 (Msh6), DNA mismatch repair protein (msh6), AU044881, AW550279, cb326, GTBP, GTMBP, Gtmbp, HNPCC5, HSAP, LOC100227810, p160, wu:fb36c12Protein level used designations for MSH6
- DNA mismatch repair protein Msh6
- G/T mismatch-binding protein
- mutS-alpha 160 kDa subunit
- sperm-associated protein
- mutS homolog 6 (E. coli)
- DNA mismatch repair protein Msh6-like
- g/T mismatch-binding protein
- p160
- rCG61559-like
- LOW QUALITY PROTEIN: DNA mismatch repair protein Msh6
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