MRPS12 Products
(Mitochondrial Ribosomal Protein S12 (MRPS12))
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene\; all three variants encode the same protein. [provided by RefSeq, Jul 2008].
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Featured MRPS12 Categories
MRPS12 Antibodies
High quality antibodies with extensive validation data.
MRPS12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MRPS12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN7187367
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, ICC, IF
Validations
- (2)
Cat. No.
ABIN6257348
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN656569
Quantity
400 μL
Datasheet
Datasheet
Recommended MRPS12 Proteins
Latest Publications for our MRPS12 products
: "Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma." in: The Journal of experimental medicine, Vol. 191, Issue 2, pp. 395-402, (2000) (PubMed).: "Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity." in: Annual review of immunology, Vol. 18, Issue 8, pp. 621-63, (2000) (PubMed).
Synonyms and alternative names related to MRPS12
mitochondrial ribosomal protein S12 (MRPS12), mitochondrial ribosomal protein S12 (Mrps12), technical knockout (tko), mitochondrial ribosomal protein S12 L homeolog (mrps12.L), 40S ribosomal protein S12, mitochondrial (LOC409723), mitochondrial ribosomal protein S12 (mRpS12), mitochondrial ribosomal protein S12 (mrps12), putative mitochondrial 37S ribosomal protein MRPS12 (MRPS12), putative mitochondrial 37S ribosomal protein MRPS12 (CAALFM_C106070WA), mitochondrial ribosomal protein S12 (mrpS12), fragile site, aphidicolin type, common, fra(6)(p22.2) (FRA6C), AI327385, CG7925, Dmel\\CG7925, EG:BACH59J11.1, GB10531, l(1)3Ab, l(1)tko, MGC64304, MPR-S12, MRP-S12, MRPS12, mRpS12, MT-RPS12, mt-rps12, RPMS12, Rpms12, RPS12, rps12, RPSM12, S12, TkoProtein level used designations for MRPS12
- 28S ribosomal protein S12, mitochondrial
- MRP-S12
- S12mt
- MT-RPS12
- mitoribosomal protein s12
- ribosomal protein, mitochondrial, S12
- CG7925-PB
- CG7925-PC
- mitochondrial ribosomal protein S12
- mitoribosomal protein S12
- tko-PB
- tko-PC
- Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
- Mrps12p
- likely mitochondrial ribosomal protein S12
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