Mre11 Products
(MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
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This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured Mre11 Categories
Mre11 Antibodies
High quality antibodies with extensive validation data.
Mre11 ELISA Kits
Reliable ELISA kits for a wide range of species.
Mre11 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Mre11 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (3)
- (4)
Cat. No.
ABIN3016250
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Chicken, Hamster, Human, Mouse, Rat
Application
WB, IHC, IF, IP, ICC, FACS, ChIP
Validations
- (5)
Cat. No.
ABIN363310
Quantity
0.05 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7443944
Quantity
100 μL
Datasheet
Datasheet
Recommended Mre11 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380501
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended Mre11 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1311266
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7402070
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2726317
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our Mre11 products
: "MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining." in: Molecular cell, Vol. 71, Issue 2, pp. 332-342.e8, (2019) (PubMed).: "Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination." in: Nature communications, Vol. 9, Issue 1, pp. 3872, (2019) (PubMed).
: "Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation." in: Nucleic acids research, Vol. 47, Issue 8, pp. 4068-4085, (2019) (PubMed).
: "UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. ..." in: Cell, Vol. 176, Issue 3, pp. 505-519.e22, (2019) (PubMed).
: "PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis." in: Cell reports, Vol. 26, Issue 5, pp. 1333-1343.e7, (2019) (PubMed).
: "Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription." in: Nucleic acids research, Vol. 47, Issue 13, pp. 6811-6825, (2019) (PubMed).
: "C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex." in: Molecular cell, (2019) (PubMed).
: "Increased error-free DNA repair gene expression through reprogramming in human iPS cells." in: Regenerative therapy, Vol. 11, pp. 101-105, (2019) (PubMed).
: "Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin." in: Marine drugs, Vol. 17, Issue 3, (2019) (PubMed).
: "Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223." in: Cancers, Vol. 11, Issue 12, (2019) (PubMed).
Synonyms and alternative names related to Mre11
MRE11 homolog A, double strand break repair nuclease (mre11a), MRE11 homolog, double strand break repair nuclease (MRE11), MRE11A homolog A, double strand break repair nuclease (Mre11a), MRE11 homolog A, double strand break repair nuclease (Mre11a), ATLD, HNGS1, Mre11, MRE11, Mre11b, MRE11B, wu:faa63d12, zgc:64018Protein level used designations for Mre11
- meiotic recombination 11 homolog A
- MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
- MRE11 homolog 1
- MRE11 homolog A
- double-strand break repair protein MRE11A
- meiotic recombination 11 homolog 1
- mmMRE11A
- AT-like disease
- DNA recombination and repair protein
- endo/exonuclease Mre11
- meiotic recombination 11-like protein
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