Mps1 Products
(Mps1 (TTK))
Categories
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
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Featured Mps1 Categories
Mps1 Antibodies
High quality antibodies with extensive validation data.
Mps1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Mps1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Mps1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (9)
Cat. No.
ABIN7443260
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN563279
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7443344
Quantity
100 μL
Datasheet
Datasheet
Recommended Mps1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5690965
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1130766
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385643
Quantity
96 tests
Datasheet
Datasheet
Recommended Mps1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324055
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324053
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509187
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Mps1 products
: "Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients." in: Journal of translational medicine, Vol. 12, pp. 84, (2014) (PubMed).: "High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint." in: Carcinogenesis, Vol. 32, Issue 3, pp. 305-11, (2011) (PubMed).
: "Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1. ..." in: Molecular cancer therapeutics, Vol. 10, Issue 12, pp. 2267-75, (2011) (PubMed).
: "Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores." in: The Journal of cell biology, Vol. 181, Issue 6, pp. 893-901, (2008) (PubMed).
: "Structure and evolution of mammalian ribosomal proteins." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 73, Issue 11-12, pp. 933-47, (1996) (PubMed).
Synonyms and alternative names related to Mps1
Ttk protein kinase (Ttk), TTK protein kinase (TTK), ttk protein kinase (ttk), AL022661, CT96, ESK, esk, Esk1, MPH1, MPS1, Mps1, mps1, MPS1L1, ncp, PYTProtein level used designations for Mps1
- dual specificity protein kinase TTK
- cancer/testis antigen 96
- monopolar spindle 1-like 1
- phosphotyrosine picked threonine kinase
- phosphotyrosine picked threonine-protein kinase
- dual specificity protein kinase Ttk
- mitotic checkpoint serine/threonine-protein kinase Mps1
- monopolar spindle 1
- monopolar spindle protein 1
- nightcap
- protein nightcap
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