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Mps1 Products

(Mps1 (TTK))

Categories

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].

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Featured Mps1 Categories

Mps1 Antibodies

High quality antibodies with extensive validation data.

Mps1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Mps1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Mps1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (9)
Cat. No. ABIN7443260
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (5)
Cat. No. ABIN563279
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7443344
Quantity 100 μL
Datasheet Datasheet

Recommended Mps1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5690965
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1130766
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6385643
Quantity 96 tests
Datasheet Datasheet

Recommended Mps1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324055
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324053
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509187
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Mps1 products

Iinuma, Fukushima, Inaba, Tamura, Inoue, Ogawa, Horikawa, Ikeda, Matsutani, Takeda, Yoshida, Tsunoda, Ikeda, Nakamura, Okinaga: "Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients." in: Journal of translational medicine, Vol. 12, pp. 84, (2014) (PubMed).

Niittymäki, Gylfe, Laine, Laakso, Lehtonen, Kondelin, Tolvanen, Nousiainen, Pouwels, Järvinen, Nuorva, Mecklin, Mäkinen, Ristimäki, Ørntoft, Hautaniemi, Karhu, Kallio, Aaltonen: "High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint." in: Carcinogenesis, Vol. 32, Issue 3, pp. 305-11, (2011) (PubMed).

Tardif, Rogers, Cassiano, Roth, Cimbora, McKinnon, Peterson, Douce, Robinson, Dorweiler, Davis, Hess, Ostanin, Papac, Baichwal, McAlexander, Willardsen, Saunders, Christophe, Kumar, Wettstein et al.: "Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1. ..." in: Molecular cancer therapeutics, Vol. 10, Issue 12, pp. 2267-75, (2011) (PubMed).

Tighe, Staples, Taylor: "Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores." in: The Journal of cell biology, Vol. 181, Issue 6, pp. 893-901, (2008) (PubMed).

Wool, Chan, Glück: "Structure and evolution of mammalian ribosomal proteins." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 73, Issue 11-12, pp. 933-47, (1996) (PubMed).

Synonyms and alternative names related to Mps1

Ttk protein kinase (Ttk), TTK protein kinase (TTK), ttk protein kinase (ttk), AL022661, CT96, ESK, esk, Esk1, MPH1, MPS1, Mps1, mps1, MPS1L1, ncp, PYT

Protein level used designations for Mps1

  • dual specificity protein kinase TTK
  • cancer/testis antigen 96
  • monopolar spindle 1-like 1
  • phosphotyrosine picked threonine kinase
  • phosphotyrosine picked threonine-protein kinase
  • dual specificity protein kinase Ttk
  • mitotic checkpoint serine/threonine-protein kinase Mps1
  • monopolar spindle 1
  • monopolar spindle protein 1
  • nightcap
  • protein nightcap
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