MMP12 Products
(Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))
Categories
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].
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Featured MMP12 Categories
MMP12 Antibodies
High quality antibodies with extensive validation data.
MMP12 ELISA Kits
Reliable ELISA kits for a wide range of species.
MMP12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MMP12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), IF
Validations
- (3)
- (6)
Cat. No.
ABIN390136
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7437821
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7431755
Quantity
100 μL
Datasheet
Datasheet
Recommended MMP12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN6720563
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6961934
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957679
Quantity
96 tests
Datasheet
Datasheet
Recommended MMP12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311064
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311062
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7320612
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our MMP12 products
: "Infection of Mycobacterium tuberculosis Promotes Both M1/M2 Polarization and MMP Production in Cigarette Smoke-Exposed Macrophages." in: Frontiers in immunology, Vol. 11, pp. 1902, (2020) (PubMed).: "Biomarkers of oxidative stress and protein-protein interaction in chronic obstructive pulmonary disease." in: Archives of physiology and biochemistry, Vol. 124, Issue 3, pp. 226-231, (2019) (PubMed).
: "Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis." in: Anticancer research, Vol. 38, Issue 12, pp. 6663-6667, (2019) (PubMed).
: "Dietary DNA Attenuates the Degradation of Elastin Fibers in the Aortic Wall in Nicotine-Administrated Mice." in: Journal of nutritional science and vitaminology, Vol. 64, Issue 4, pp. 271-276, (2019) (PubMed).
: "Concomitant elevations of MMP-9, NGAL, proMMP-9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease." in: Journal of cellular and molecular medicine, Vol. 21, Issue 7, pp. 1280-1291, (2018) (PubMed).
: "Orthodontic tensile strain induces angiogenesis via type IV collagen degradation by matrix metalloproteinase-12." in: Journal of periodontal research, Vol. 52, Issue 5, pp. 842-852, (2018) (PubMed).
: "Elastin‑derived peptides are involved in the processes of human temporomandibular disorder by inducing inflammatory responses in synovial cells." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 3147-3154, (2018) (PubMed).
: "Acute Moraxella catarrhalis Airway Infection of Chronically Smoke-Exposed Mice Increases Mechanisms of Emphysema Development: A Pilot Study." in: European journal of microbiology & immunology, Vol. 8, Issue 4, pp. 128-134, (2018) (PubMed).
: "Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice." in: Food & function, Vol. 8, Issue 8, pp. 2829-2835, (2017) (PubMed).
: "Down-regulation of Toll-like Receptor TLR4 Is Associated with HPV DNA Integration in Penile Carcinoma." in: Anticancer research, Vol. 37, Issue 10, pp. 5515-5519, (2017) (PubMed).
Synonyms and alternative names related to MMP12
matrix metallopeptidase 12 (MMP12), matrix metallopeptidase 12 (Mmp12), AV378681, HME, ME, Mme, MME, Mmel, MMP-12, MMP12Protein level used designations for MMP12
- matrix metallopeptidase 12 (macrophage elastase)
- matrix metalloproteinase 12
- MME
- MMP-12
- macrophage elastase
- macrophage metalloelastase
- macrophage-metalloelastase
- matrix metalloproteinase-12
- matrix metalloproteinase 12 (macrophage elastase)
- macrophage metalloelastase MMP-12
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