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MKNK1 Products

(MAP Kinase Interacting serine/threonine Kinase 1 (MKNK1))

Categories

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012].

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Featured MKNK1 Categories

MKNK1 Antibodies

High quality antibodies with extensive validation data.

MKNK1 ELISA Kits

Reliable ELISA kits for a wide range of species.

MKNK1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MKNK1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (6)
Cat. No. ABIN563699
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (4)
Cat. No. ABIN522034
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (4)
Cat. No. ABIN522031
Quantity 100 μg
Datasheet Datasheet

Recommended MKNK1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380779
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380848
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended MKNK1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310976
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310974
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509020
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our MKNK1 products

Girotti, Silva, George, Morilak: "Ciliary neurotrophic factor signaling in the rat orbitofrontal cortex ameliorates stress-induced deficits in reversal learning." in: Neuropharmacology, Vol. 160, pp. 107791, (2019) (PubMed).

Pan, Hou, Zhang, Zhao, Hua, Wang, He, Jiang, Hu, Zhang: "Inhibitory effect and molecular mechanism of mesenchymal stem cells on NSCLC cells." in: Molecular and cellular biochemistry, Vol. 441, Issue 1-2, pp. 63-76, (2018) (PubMed).

Cuesta, Xi, Schneider: "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein." in: Journal of virology, Vol. 78, Issue 14, pp. 7707-16, (2004) (PubMed).

Orton, Ling, Waskiewicz, Cooper, Merrick, Korneeva, Rhoads, Sonenberg, Traugh: "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38649-57, (2004) (PubMed).

Ueda, Watanabe-Fukunaga, Fukuyama, Nagata, Fukunaga: "Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6539-49, (2004) (PubMed).

OLoghlen, González, Piñeiro, Pérez-Morgado, Salinas, Martín: "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1." in: Experimental cell research, Vol. 299, Issue 2, pp. 343-55, (2004) (PubMed).

Knauf, Tschopp, Gram: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2." in: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5500-11, (2001) (PubMed).

Pyronnet: "Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1." in: Biochemical pharmacology, Vol. 60, Issue 8, pp. 1237-43, (2000) (PubMed).

Fukunaga, Hunter: "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates." in: The EMBO journal, Vol. 16, Issue 8, pp. 1921-33, (1997) (PubMed).

Synonyms and alternative names related to MKNK1

MAP kinase interacting serine/threonine kinase 1 (MKNK1), MAP kinase interacting serine/threonine kinase 1 (mknk1), MAP kinase-interacting serine/threonine kinase 1 (Mknk1), MAP kinase interacting serine/threonine kinase 1 (Mknk1), MAP kinase interacting serine/threonine kinase 1 S homeolog (mknk1.S), 2410048M24Rik, MAPK signal-integrating kinase 1, MKNK1, mknk1, MNK1, Mnk1, mnk1, zgc:171912

Protein level used designations for MKNK1

  • MAP kinase signal-integrating kinase 1
  • MAP kinase-interacting serine/threonine-protein kinase 1
  • MAPK signal-integrating kinase 1
  • MAP kinase interacting serine/threonine kinase 1
  • mnk1
  • MAP kinase-interacting kinase 1
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