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Mitogen-Activated Protein Kinase Kinase 4 Products

(Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Categories

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008].

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Featured Mitogen-Activated Protein Kinase Kinase 4 Categories

Mitogen-Activated Protein Kinase Kinase 4 Antibodies

High quality antibodies with extensive validation data.

Mitogen-Activated Protein Kinase Kinase 4 ELISA Kits

Reliable ELISA kits for a wide range of species.

Mitogen-Activated Protein Kinase Kinase 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Mitogen-Activated Protein Kinase Kinase 4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p), IP, FACS
Validations
  • (8)
Cat. No. ABIN1499480
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p), IP
Validations
  • (11)
Cat. No. ABIN1499481
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IHC (p)
Validations
  • (6)
Cat. No. ABIN1499482
Quantity 100 μL
Datasheet Datasheet

Recommended Mitogen-Activated Protein Kinase Kinase 4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380697
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380698
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6219584
Quantity 96 tests
Datasheet Datasheet

Recommended Mitogen-Activated Protein Kinase Kinase 4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124001
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310179
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310181
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Mitogen-Activated Protein Kinase Kinase 4 products

Li, Zhang, Zhu, Ashraf, Chen, Xu, Zhou, Zheng, Song, Chen, Ye, Cao: "Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection." in: Frontiers in immunology, Vol. 8, pp. 1237, (2017) (PubMed).

Rho, Lampe: "High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays." in: Journal of proteome research, Vol. 12, Issue 5, pp. 2311-20, (2013) (PubMed).

Saha, Jiang, Yang, Zhu, Wang, Schimmer, Qiu, Chang: "Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma." in: PLoS ONE, Vol. 7, Issue 1, pp. e30215, (2012) (PubMed).

Song, Coffa, Fu, Gurevich: "How does arrestin assemble MAPKs into a signaling complex?" in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 685-95, (2008) (PubMed).

Robinson, Shalhav, Otto, Kawai, Gorospe, Rinker-Schaeffer: "Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines." in: Molecular cancer research : MCR, Vol. 6, Issue 3, pp. 501-8, (2008) (PubMed).

Austin, Rune, Bouzakri, Zierath, Krook: "siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle." in: Diabetes, Vol. 57, Issue 8, pp. 2066-73, (2008) (PubMed).

Yoshizawa, Hammaker, Sweeney, Boyle, Firestein: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, (2008) (PubMed).

Xia, Srinivas, Ahn, Sethi, Sheng, Yung, Xia, Chiao, Kim, Brown, Wistuba, Aggarwal, Kurie: "Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway." in: The Journal of biological chemistry, Vol. 282, Issue 6, pp. 3507-19, (2007) (PubMed).

Zhang, Zhang, Zhang, Lin, Li, Pober, Min: "RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation." in: The Journal of biological chemistry, Vol. 282, Issue 20, pp. 14788-96, (2007) (PubMed).

Stark, Tongers, Maass, Mehdorn, Held-Feindt: "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases." in: Journal of cancer research and clinical oncology, Vol. 131, Issue 3, pp. 191-8, (2005) (PubMed).

Synonyms and alternative names related to Mitogen-Activated Protein Kinase Kinase 4

mitogen-activated protein kinase kinase 4 (MAP2K4), mitogen-activated protein kinase kinase 4 (Map2k4), mitogen-activated protein kinase kinase 4a (map2k4a), mitogen-activated protein kinase kinase 4 (map2k4), MAP kinase kinase 4 (Mkk4), mitogen activated protein kinase kinase 4 (Map2k4), mitogen-activated protein kinase kinase 4 (MKK4), mitogen-activated protein kinase kinase 4b (map2k4b), 142758_at, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, CG9738, CT27508, D-MKK4, Dmel\\CG9738, DMKK4, dMKK4, dMkk4, F19C24.26, F19C24_26, hep, JNKK, jnkk, JNKK1, jnkk1, JNKK2, map2k4, MAP KINASE KINASE 4, MAPKK4, mapkk4, MEK4, mek4, mitogen-activated protein kinase kinase 4, MKK4, mkk4, MKK4A-l, MKK4B, Mpk4, PRKMK4, prkmk4, SAPKK-1, SAPKK1, SEK1, Sek1, sek1, SEK1/MKK4, SERK1, Serk1, serk1, SKK1, xmek2, zgc:136500, zgc:194486

Protein level used designations for Mitogen-Activated Protein Kinase Kinase 4

  • JNK activating kinase 1
  • JNK-activated kinase 1
  • JNK-activating kinase 1
  • MAP kinase kinase 4
  • MAPK/ERK kinase 4
  • MAPKK 4
  • MEK 4
  • SAPK/ERK kinase 1
  • c-Jun N-terminal kinase kinase 1
  • dual specificity mitogen-activated protein kinase kinase 4
  • stress-activated protein kinase kinase 1
  • C-JUN N-terminal kinase kinase 1
  • JNK kinase 1
  • JNKK 1
  • SAPK/Erk/kinase 1
  • mitogen activated protein kinase kinase 4, variant 1
  • mitogen-activated protein kinase kinase 4
  • mkk4a
  • CG9738-PA
  • CG9738-PB
  • CG9738-PC
  • JNK kinase 2
  • Map kinase kinase 4
  • Mkk4-PA
  • Mkk4-PB
  • Mkk4-PC
  • drosophila MAP kinase kinase 4
  • MAP2K4delta
  • MAP kinase kinase 4B
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