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Mitogen-Activated Protein Kinase Kinase 2 Products

(Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Categories

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].

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Featured Mitogen-Activated Protein Kinase Kinase 2 Categories

Mitogen-Activated Protein Kinase Kinase 2 Antibodies

High quality antibodies with extensive validation data.

Mitogen-Activated Protein Kinase Kinase 2 ELISA Kits

Reliable ELISA kits for a wide range of species.

Mitogen-Activated Protein Kinase Kinase 2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Mitogen-Activated Protein Kinase Kinase 2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
  • (3)
  • (1)
Cat. No. ABIN726500
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7439504
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF, IHC (p)
Validations
  • (5)
Cat. No. ABIN392485
Quantity 400 μL
Datasheet Datasheet

Recommended Mitogen-Activated Protein Kinase Kinase 2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380638
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730501
Quantity 96 tests
Datasheet Datasheet
Reactivity Dog
Analytical Method
Validations
Cat. No. ABIN1130729
Quantity 96 tests
Datasheet Datasheet

Recommended Mitogen-Activated Protein Kinase Kinase 2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Source Insect cells (Sf9)
Validations
  • (1)
Cat. No. ABIN5624615
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123999
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310171
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Mitogen-Activated Protein Kinase Kinase 2 products

Guo, Wang, Li, Sun, Zhang, Hao: "Follicular fluid meiosis-activating sterol (FF-MAS) promotes meiotic resumption via the MAPK pathway in porcine oocytes." in: Theriogenology, (2019) (PubMed).

Shaul, Seger: "The MEK/ERK cascade: from signaling specificity to diverse functions." in: Biochimica et biophysica acta, Vol. 1773, Issue 8, pp. 1213-26, (2007) (PubMed).

Mittal, Peak-Chew, McMahon: "Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18574-9, (2006) (PubMed).

Burroughs, Oh, Barrett, DiAugustine et al.: "Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible ..." in: Molecular cancer research : MCR, Vol. 1, Issue 4, pp. 312-22, (2003) (PubMed).

Tran, Maurer, Nagamine: "Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2." in: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7177-88, (2003) (PubMed).

Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).

Li, Inoki, Vacratsis, Guan: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, (2003) (PubMed).

Synonyms and alternative names related to Mitogen-Activated Protein Kinase Kinase 2

mitogen-activated protein kinase kinase 2 (MAP2K2), mitogen-activated protein kinase kinase 2 (Map2k2), mitogen activated protein kinase kinase 2 (Map2k2), MAP kinase kinase 2 (MKK2), mitogen-activated protein kinase kinase 2a (map2k2a), mitogen-activated protein kinase kinase 2b (map2k2b), AA589381, ATMKK2, CFC4, F27B13.50, F27B13_50, map2k2, MAP KINASE KINASE 1, MAP kinase kinase 2, MAPKK2, MEK2, MK1, MK2, MKK2, PRKMK2, Prkmk2, wu:fa56c06, zgc:123171, zgc:172250

Protein level used designations for Mitogen-Activated Protein Kinase Kinase 2

  • ERK activator kinase 2
  • MAP kinase kinase 2
  • MAPK/ERK kinase 2
  • dual specificity mitogen-activated protein kinase kinase 2
  • mitogen-activated protein kinase kinase 2, p45
  • MAP kinase/Erk kinase
  • MAPKK 2
  • MEK 2
  • mitogen activated protein kinase kinase 2
  • protein kinase, mitogen activated, kinase 2, p45
  • MEK2
  • mitogen-activated protein kinase kinase type 2
  • dual specificity mitogen activated protein kinase kinase 2
  • fa56c06
  • mitogen-activated protein kinase kinase 2
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