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Metabotropic Glutamate Receptor 5 Products

(Glutamate Receptor, Metabotropic 5 (GRM5))
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].

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Featured Metabotropic Glutamate Receptor 5 Categories

Metabotropic Glutamate Receptor 5 Antibodies

High quality antibodies with extensive validation data.

Metabotropic Glutamate Receptor 5 ELISA Kits

Reliable ELISA kits for a wide range of species.

Metabotropic Glutamate Receptor 5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Metabotropic Glutamate Receptor 5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA, ICC
Validations
  • (6)
Cat. No. ABIN5611178
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, ICC, LCI
Validations
  • (5)
Cat. No. ABIN7043250
Quantity 25 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IF, IP, ICC
Validations
  • (3)
Cat. No. ABIN1027721
Quantity 100 μg
Datasheet Datasheet

Recommended Metabotropic Glutamate Receptor 5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967067
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1743303
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1774208
Quantity 96 tests
Datasheet Datasheet

Recommended Metabotropic Glutamate Receptor 5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1355782
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Mammalian Cells
Validations
Cat. No. ABIN7538304
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Metabotropic Glutamate Receptor 5 products

Lee, Vyas, Garner, Montgomery: "Autism-associated Shank3 mutations alter mGluR expression and mGluR-dependent but not NMDA receptor-dependent long-term depression." in: Synapse (New York, N.Y.), Vol. 73, Issue 8, pp. e22097, (2019) (PubMed).

Cheyne, Grant, Butler-Munro, Foote, Connor, Montgomery: "Synaptic integration of newly generated neurons in rat dissociated hippocampal cultures." in: Molecular and cellular neurosciences, Vol. 47, Issue 3, pp. 203-14, (2011) (PubMed).

Spanagel, Pendyala, Abarca, Zghoul, Sanchis-Segura, Magnone, Lascorz, Depner, Holzberg, Soyka, Schreiber, Matsuda, Lathrop, Schumann, Albrecht: "The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption." in: Nature medicine, Vol. 11, Issue 1, pp. 35-42, (2005) (PubMed).

Pacheco, Ciruela, Casadó, Mallol, Gallart, Lluis, Franco: "Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33352-8, (2004) (PubMed).

Uchino, Sakai, Kashiwagi, Shirai, Shinohara, Hirose, Iino, Yamamura, Saito: "Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 2254-61, (2004) (PubMed).

Anneser, Ince, Shaw, Borasio: "Differential expression of mGluR5 in human lumbosacral motoneurons." in: Neuroreport, Vol. 15, Issue 2, pp. 271-3, (2004) (PubMed).

Synonyms and alternative names related to Metabotropic Glutamate Receptor 5

glutamate receptor, metabotropic 5 (GRM5), glutamate metabotropic receptor 5 (GRM5), glutamate metabotropic receptor 5 (Grm5), glutamate receptor, metabotropic 5 (Grm5), 6430542K11Rik, AI850523, Glu5R, GPRC1E, Gprc1e, mGlu5, MGLUR5, mGluR5, mGlur5, mGluR5b

Protein level used designations for Metabotropic Glutamate Receptor 5

  • metabotropic glutamate receptor 5
  • metabotropic glutamate receptor 5 variant F
  • metabotropic glutamate receptor 5 variant G
  • metabotropic glutamate receptor 5 variant H
  • metabotropic glutamate receptor (mGluR5)
  • metabotropic glutamate receptor 5b
  • G protein coupled receptor, family C, group 1, member E
  • G protein-coupled receptor GRM5
  • G protein-coupled receptor, family C, group 1, member E
  • metabotropic glutamate receptor subtype 5b
  • metabotropic glutamate receptor type 5
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