MED23 Products
(Mediator Complex Subunit 23 (MED23))
Categories
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012].
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Featured MED23 Categories
MED23 Antibodies
High quality antibodies with extensive validation data.
MED23 ELISA Kits
Reliable ELISA kits for a wide range of species.
MED23 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MED23 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7159128
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (1)
Cat. No.
ABIN7003463
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF
Validations
- (1)
Cat. No.
ABIN7188664
Quantity
100 μg
Datasheet
Datasheet
Recommended MED23 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743282
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1774187
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1744501
Quantity
96 tests
Datasheet
Datasheet
Recommended MED23 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310655
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093769
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136081
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MED23 products
: "Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development." in: Nature communications, Vol. 7, pp. 11149, (2016) (PubMed).: "LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation." in: Neuron, Vol. 86, Issue 3, pp. 696-710, (2015) (PubMed).
: "The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination." in: The EMBO journal, Vol. 34, Issue 23, pp. 2885-902, (2015) (PubMed).
: "T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs." in: PLoS ONE, Vol. 9, Issue 7, pp. e102076, (2015) (PubMed).
: "The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation." in: Experimental neurology, Vol. 253, pp. 126-37, (2014) (PubMed).
: "Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity." in: Cell research, Vol. 24, Issue 10, pp. 1250-65, (2014) (PubMed).
: "Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation." in: Journal of virology, Vol. 86, Issue 15, pp. 8198-209, (2012) (PubMed).
: "Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves." in: Molecular and cellular biology, Vol. 32, Issue 1, pp. 199-205, (2011) (PubMed).
: "Core promoter recognition complex changes accompany liver development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 10, pp. 3906-11, (2011) (PubMed).
: "Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3." in: The EMBO journal, Vol. 27, Issue 10, pp. 1447-57, (2008) (PubMed).
Synonyms and alternative names related to MED23
Mediator complex subunit 23 (MED23), mediator complex subunit 23 (MED23), mediator complex subunit 23 (med23), mediator of RNA polymerase II transcription subunit 23 (LOC412332), mediator complex subunit 23 (Med23), mediator complex subunit 23 L homeolog (med23.L), Mediator of RNA polymerase II transcription subunit 23 (sur-2), 130kDa, 3000002A17Rik, ARC130, CG3695, CRSP3, Crsp3, crsp3, CRSP130, CRSP133, Dmel\\CG3695, DRIP130, dSUR2, dTRAP150beta, ESTM7, Gal11/SUR2, Med23, MED23, mKIAA1216, MRT18, si:ch211-272f15.2, SUR-2, SUR2, Sur2, Trap150, Trap150beta, X83317, zgc:91979Protein level used designations for MED23
- CG3695-PA
- CG3695-PB
- MED23-PA
- MED23-PB
- mediator complex subunit 23
- mediator complex subunit n23
- cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa
- Sp1 transcriptional activation cofactor subunit 3
- mediator of RNA polymerase II transcription subunit 23-like
- mediator of RNA polymerase II transcription subunit 23
- 130 kDa transcriptional co-activator
- 133 kDa transcriptional co-activator
- activator-recruited cofactor 130 kDa component
- cofactor required for Sp1 transcriptional activation subunit 3
- vitamin D3 receptor interacting protein
- CRSP complex subunit 3
- cofactor required for Sp1 transcriptional activation, subunit 3 (130kD)
- mSur-2
- protein sur-2 homolog
- cofactor required for Sp1 transcriptional activation, subunit 3
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