MED12 Products
(Mediator Complex Subunit 12 (MED12))
Categories
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
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Featured MED12 Categories
MED12 Antibodies
High quality antibodies with extensive validation data.
MED12 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended MED12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN6242936
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7159104
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7243679
Quantity
200 μL
Datasheet
Datasheet
Recommended MED12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743269
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1774174
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1744488
Quantity
96 tests
Datasheet
Datasheet
Recommended MED12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310630
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MED12 products
: "H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas." in: Oncogene, Vol. 38, Issue 27, pp. 5356-5366, (2019) (PubMed).: "Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6." in: Journal of medicinal chemistry, Vol. 59, Issue 19, pp. 9124-9139, (2016) (PubMed).
: "Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 15, pp. 6679-90, (2013) (PubMed).
: "Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription." in: PLoS ONE, Vol. 8, Issue 10, pp. e78242, (2013) (PubMed).
: "Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation." in: Biochimie, Vol. 94, Issue 8, pp. 1828-32, (2012) (PubMed).
: "Control of ground-state pluripotency by allelic regulation of Nanog." in: Nature, Vol. 483, Issue 7390, pp. 470-3, (2012) (PubMed).
: "MED12 alterations in both human benign and malignant uterine soft tissue tumors." in: PLoS ONE, Vol. 7, Issue 6, pp. e40015, (2012) (PubMed).
: "Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines." in: Experimental hematology, Vol. 40, Issue 10, pp. 800-10, (2012) (PubMed).
: "A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 2, pp. 348-59, (2011) (PubMed).
: "Core promoter recognition complex changes accompany liver development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 10, pp. 3906-11, (2011) (PubMed).
Synonyms and alternative names related to MED12
mediator complex subunit 12 (MED12), mediator complex subunit 12 (Med12), mediator complex subunit 12 (med12), 230kDa, ARC240, CAGH45, FGS1, HOPA, MED12S, Mopa, OHDOX, OKS, OPA-1, OPA1, TNRC11, Tnrc11, TRAP230, Trap230Protein level used designations for MED12
- CAG repeat protein 45
- OPA-containing protein
- activator-recruited cofactor 240 kDa component
- human opposite paired
- mediator of RNA polymerase II transcription subunit 12
- mediator of RNA polymerase II transcription, subunit 12 homolog
- putative mediator subunit 12
- thyroid hormone receptor-associated protein complex 230 kDa component
- thyroid hormone receptor-associated protein, 230 kDa subunit
- trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
- trinucleotide repeat-containing gene 11 protein
- trinucleotide repeat containing 11
- OPA-containing protein 1
- mediator complex subunit 12
- trinucleotide repeat containing 11 (THR-associated protein)
- kohtalo
- kto
- mot_m807
- motionless
- protein kohtalo
- protein motionless
- shiri
- shr
- thyroid hormone receptor-associated protein 230
- thyroid hormone receptor-associated protein complex component TRAP230
- trap230
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