MDM4-binding Protein Products
(Mdm4-binding Protein (MDM4))
Categories
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
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MDM4-binding Protein Antibodies
High quality antibodies with extensive validation data.
MDM4-binding Protein ELISA Kits
Reliable ELISA kits for a wide range of species.
MDM4-binding Protein Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MDM4-binding Protein Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (8)
Cat. No.
ABIN948119
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC
Validations
- (2)
- (4)
Cat. No.
ABIN969282
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN1499354
Quantity
100 μL
Datasheet
Datasheet
Recommended MDM4-binding Protein ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381305
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951175
Quantity
96 tests
Datasheet
Datasheet
Recommended MDM4-binding Protein Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123869
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123868
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310606
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MDM4-binding Protein products
: "MDM4 expression in fibrolamellar hepatocellular carcinoma." in: Oncology reports, (2019) (PubMed).: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." in: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).
: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." in: Oncogene, (2015) (PubMed).
: "Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach." in: Chemical biology & drug design, Vol. 86, Issue 2, pp. 180-9, (2015) (PubMed).
: "Protumorigenic role of Timeless in hepatocellular carcinoma." in: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).
: "EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma." in: Hepatology (Baltimore, Md.), Vol. 59, Issue 5, pp. 1886-99, (2014) (PubMed).
: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).
: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).
: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).
: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).
Synonyms and alternative names related to MDM4-binding Protein
MDM4, p53 regulator S homeolog (mdm4.S), MDM4, p53 regulator (MDM4), MDM4, p53 regulator (Mdm4), MDM4, p53 regulator (mdm4), transformed mouse 3T3 cell double minute 4 (Mdm4), 4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, mdmx, MDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10Protein level used designations for MDM4-binding Protein
- double minute 4 protein
- mdm2-like p53-binding protein
- p53-binding protein Mdm4
- protein Mdm4
- MDM4-related protein 1
- double minute 4, human homolog of; p53-binding protein
- protein Mdmx
- Mdm4, transformed 3T3 cell double minute 4, p53 binding protein
- double minute 4 homolog
- transformed mouse 3T3 cell double minute 4
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