MDC1 Products
(Mdc1 (MDC1))
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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008].
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Featured MDC1 Categories
MDC1 Antibodies
High quality antibodies with extensive validation data.
Recommended MDC1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (2)
- (3)
Cat. No.
ABIN2855454
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN6143659
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
Cat. No.
ABIN739740
Quantity
100 μL
Datasheet
Datasheet
Recommended MDC1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228688
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our MDC1 products
: "JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity." in: Cell death and differentiation, (2019) (PubMed).: "Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks." in: Nucleic acids research, Vol. 47, Issue 7, pp. 3467-3484, (2019) (PubMed).
: "SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression." in: Scientific reports, Vol. 7, Issue 1, pp. 3842, (2017) (PubMed).
: "RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9396-410, (2016) (PubMed).
: "Coordination of the recruitment of the FANCD2 and PALB2 Fanconi anemia proteins by an ubiquitin signaling network." in: Chromosoma, (2016) (PubMed).
: "Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites." in: Nucleic acids research, Vol. 44, Issue 3, pp. e27, (2016) (PubMed).
: "The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex." in: PLoS ONE, Vol. 10, Issue 12, pp. e0144957, (2015) (PubMed).
: "The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence." in: Molecular and cellular biology, Vol. 34, Issue 10, pp. 1733-46, (2014) (PubMed).
: "DNA damage to a single chromosome end delays anaphase onset." in: The Journal of biological chemistry, Vol. 289, Issue 33, pp. 22771-84, (2014) (PubMed).
: "Listeria monocytogenes dampens the DNA damage response." in: PLoS pathogens, Vol. 10, Issue 10, pp. e1004470, (2014) (PubMed).
Synonyms and alternative names related to MDC1
mediator of DNA damage checkpoint 1 (Mdc1), mediator of DNA damage checkpoint 1 (MDC1), mediator of DNA-damage checkpoint 1 (MDC1), 6820401C03, AA413496, mKIAA0170, Nfbd1, NFBD1Protein level used designations for MDC1
- mediation of DNA damage checkpoint 1
- mediator of DNA damage checkpoint protein 1
- homologue to Drosophila photoreceptor protein calphotin
- mediator of DNA damage checkpoint 1
- nuclear factor with BRCT domains 1
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