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MCM8 Products

(Minichromosome Maintenance Deficient 8 (MCM8))

Categories

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

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Featured MCM8 Categories

MCM8 Antibodies

High quality antibodies with extensive validation data.

MCM8 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MCM8 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (1)
  • (3)
Cat. No. ABIN309831
Quantity 25 μL
Datasheet Datasheet
Reactivity Bat, Cow, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6737804
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN529702
Quantity 100 μg
Datasheet Datasheet

Recommended MCM8 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6211736
Quantity 96 tests
Datasheet Datasheet

Recommended MCM8 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1310565
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1990369
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505291
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MCM8 products

Inano, Sato, Katsuki, Kobayashi, Tanaka, Nakajima, Nakada, Miyoshi, Knies, Takaori-Kondo, Schindler, Ishiai, Kurumizaka, Takata: "RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination." in: Molecular cell, Vol. 66, Issue 5, pp. 622-634.e8, (2017) (PubMed).

Park, Long, Lee, Abbas, Shibata, Negishi, Luo, Schimenti, Gambus, Walter, Dutta: "The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination." in: Molecular and cellular biology, Vol. 33, Issue 8, pp. 1632-44, (2013) (PubMed).

Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." in: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).

Ono, Kumai, Koizumi, Nishikawa, Kobayashi, Tadokoro: "Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues." in: Human pathology, Vol. 40, Issue 1, pp. 41-9, (2008) (PubMed).

Synonyms and alternative names related to MCM8

minichromosome maintenance 8 homologous recombination repair factor (MCM8), minichromosome maintenance 8 homologous recombination repair factor (Mcm8), minichromosome maintenance 8 homologous recombination repair factor L homeolog (mcm8.L), 5730432L01Rik, C20orf154, dJ967N21.5

Protein level used designations for MCM8

  • DNA helicase MCM8
  • DNA replication licensing factor MCM8
  • MCM8 minichromosome maintenance deficient 8
  • REC homolog
  • minichromosome maintenance 8
  • minichromosome maintenance deficient 8
  • Minichromosome maintenance 8
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