MCM7 Products
(Minichromosome Maintenance Complex Component 7 (MCM7))
Categories
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured MCM7 Categories
MCM7 Antibodies
High quality antibodies with extensive validation data.
MCM7 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCM7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, ELISA, IHC (p), PLA
Validations
- (4)
- (7)
Cat. No.
ABIN561764
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC, ChIP
Validations
- (5)
Cat. No.
ABIN2856749
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
Cat. No.
ABIN3021521
Quantity
100 μL
Datasheet
Datasheet
Recommended MCM7 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310563
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130497
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5853499
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our MCM7 products
: "JMJD5 (Jumonji Domain-containing 5) Associates with Spindle Microtubules and Is Required for Proper Mitosis." in: The Journal of biological chemistry, Vol. 291, Issue 9, pp. 4684-97, (2016) (PubMed).: "Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate." in: Oncotarget, Vol. 5, Issue 5, pp. 1326-37, (2014) (PubMed).
: "Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 32, pp. E3325-34, (2014) (PubMed).
: "The miR-106b~25 cluster promotes bypass of doxorubicin-induced senescence and increase in motility and invasion by targeting the E-cadherin transcriptional activator EP300." in: Cell death and differentiation, Vol. 21, Issue 3, pp. 462-74, (2014) (PubMed).
: "A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication." in: Science signaling, Vol. 6, Issue 262, pp. ra10, (2013) (PubMed).
: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." in: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).
: "MCM proteins are negative regulators of hypoxia-inducible factor 1." in: Molecular cell, Vol. 42, Issue 5, pp. 700-12, (2011) (PubMed).
: "Validation of different replication markers for the detection of beta-cell proliferation in human pancreatic tissue." in: Regulatory peptides, Vol. 162, Issue 1-3, pp. 115-21, (2010) (PubMed).
: "Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion." in: Oncogene, Vol. 29, Issue 40, pp. 5475-89, (2010) (PubMed).
: "Etiological role of human papillomavirus infection for inverted papilloma of the bladder." in: Journal of medical virology, Vol. 83, Issue 2, pp. 277-85, (2010) (PubMed).
Synonyms and alternative names related to MCM7
minichromosome maintenance complex component 7 (MCM7), mini-chromosome maintenance complex protein 7 (MCM7), mini-chromosome maintenance complex protein 7 (CDC47), minichromosome maintenance complex component 7 (Mcm7), minichromosome maintenance complex component 2 (MCM2), minichromosome maintenance complex component 7 (mcm7), minichromosome maintenance complex component 7 L homeolog (mcm7.L), Minichromosome maintenance 7 (Mcm7), minichromosome maintenance complex component 7 S homeolog (mcm7.S), MCM complex subunit Mcm7 (mcm7), AI747533, anon-EST:Liang-1.66, CDC47, cdc47, cdc47-2, CG4978, chunp6911, clone 1.66, Dmel\\CG4978, DmeMCM7, DmMCM7, mCDC47, MCM2, MCM7, mcm7, McM7, Mcmd7, Mcp-PCR1, nyz175, P1.1-MCM3, P1CDC47, P85MCM, PCR1, PNAS146, sr:nyz175, xmcm7Protein level used designations for MCM7
- CDC47 homolog
- DNA replication licensing factor MCM7
- homolog of S. cerevisiae Cdc47
- minichromosome maintenance deficient 7
- hypothetical protein
- minichromosome maintenance protein 7
- MCM7 minichromosome maintenance deficient 7
- minichromosome maintenance complex component 7
- DNA replication licensing factor MCM7-like
- minichromosome maintenance complex component 2
- mini chromosome maintenance deficient 7
- CDC47 homolog B
- CDC47-2p
- DNA replication licensing factor mcm7-B
- minichromosome maintenance protein 7-B
- xMCM7-B
- CG4978-PA
- Mcm7-PA
- minichromosome maintenance 7
- minichromosome maintenance-PCR1
- CDC47 homolog A
- CDC47p
- DNA replication licensing factor mcm7-A
- XMCM7
- minichromosome maintenance protein 7-A
- p90
- xMCM7-A
- Minichromosome maintenance protein 7
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