MCM6 Products
(Minichromosome Maintenance Complex Component 6 (MCM6))
Categories
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012].
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Featured MCM6 Categories
MCM6 Antibodies
High quality antibodies with extensive validation data.
MCM6 ELISA Kits
Reliable ELISA kits for a wide range of species.
MCM6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCM6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (7)
Cat. No.
ABIN3022687
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, StM
Validations
- (5)
Cat. No.
ABIN6940016
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), PLA
Validations
- (5)
Cat. No.
ABIN517783
Quantity
50 μg
Datasheet
Datasheet
Recommended MCM6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968631
Quantity
96 tests
Datasheet
Datasheet
Recommended MCM6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310559
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310561
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093725
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MCM6 products
: "MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 10, (2018) (PubMed).: "Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate." in: Oncotarget, Vol. 5, Issue 5, pp. 1326-37, (2014) (PubMed).
: "Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells." in: Nature, Vol. 512, Issue 7513, pp. 198-202, (2014) (PubMed).
: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." in: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).
: "A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 6, pp. 1490-501, (2011) (PubMed).
: "Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins." in: Journal of virology, Vol. 82, Issue 3, pp. 1458-64, (2008) (PubMed).
: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).
: "Stepwise regulated chromatin assembly of MCM2-7 proteins." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8426-31, (2000) (PubMed).
: "Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex." in: Molecular and cellular biology, Vol. 20, Issue 10, pp. 3667-76, (2000) (PubMed).
: "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8003-15, (2000) (PubMed).
Synonyms and alternative names related to MCM6
Minichromosome maintenance 6 (Mcm6), DNA replication licensing factor MCM6 (TP02_0113), DNA replication licensing factor MCM6 (PVX_114735), DNA replication licensing factor MCM6 (CMU_027970), minichromosome maintenance complex component 6 (MCM6), minichromosome maintenance complex component 6 (Mcm6), minichromosome maintenance complex component 6 L homeolog (mcm6.L), DNA replication licensing factor mcm-6 (mcm-6), ASP-l1, CG4039, D1Wsu22e, Dmel\\CG4039, DmeMCM6, DmMCM6, fs(1)K1214, MCG40308, MCM6, McM6, mcm6, Mcmd6, Mis5, mis5, mmcm6, P105MCMProtein level used designations for MCM6
- CG4039-PA
- Mcm6-PA
- female sterile(1)K1214
- minichromosome maintenance 6
- DNA replication licensing factor MCM6
- MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
- minichromosome maintenance deficient (mis5, S. pombe) 6
- minichromosome maintenance deficient 6 homolog
- intestinal DNA replication protein
- mini chromosome maintenance deficient 6
- minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
- maternal DNA replication licensing factor mcm6
- maternal minichromosome maintenance protein 6
- mis5p
- xMCM6
- mis5 homolog
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