MCM2 Products
(Minichromosome Maintenance Complex Component 2 (MCM2))
Categories
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012].
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Featured MCM2 Categories
MCM2 Antibodies
High quality antibodies with extensive validation data.
MCM2 ELISA Kits
Reliable ELISA kits for a wide range of species.
MCM2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCM2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS, ICC
Validations
- (2)
- (7)
Cat. No.
ABIN969281
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, IHC, ELISA, FACS
Validations
- (2)
- (6)
Cat. No.
ABIN969280
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP
Validations
- (6)
Cat. No.
ABIN561759
Quantity
100 μg
Datasheet
Datasheet
Recommended MCM2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957840
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381301
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN455884
Quantity
96 tests
Datasheet
Datasheet
Recommended MCM2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310547
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5709919
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our MCM2 products
: "Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 32, pp. E3325-34, (2014) (PubMed).: "A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication." in: Science signaling, Vol. 6, Issue 262, pp. ra10, (2013) (PubMed).
: "Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer." in: The Prostate, Vol. 72, Issue 14, pp. 1491-505, (2012) (PubMed).
: "Matrix-embedded endothelial cells are protected from the uremic milieu." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 26, Issue 12, pp. 3858-65, (2011) (PubMed).
: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." in: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).
: "A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 6, pp. 1490-501, (2011) (PubMed).
: "Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA." in: Nucleic acids research, Vol. 39, Issue 12, pp. 5057-66, (2011) (PubMed).
: "Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition." in: The Journal of biological chemistry, Vol. 286, Issue 26, pp. 23031-43, (2011) (PubMed).
: "HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression." in: Cancer research, Vol. 71, Issue 17, pp. 5621-5, (2011) (PubMed).
: "MCM proteins are negative regulators of hypoxia-inducible factor 1." in: Molecular cell, Vol. 42, Issue 5, pp. 700-12, (2011) (PubMed).
Synonyms and alternative names related to MCM2
Minichromosome maintenance 2 (Mcm2), minichromosome maintenance complex component 2 (mcm2), minichromosome maintenance complex component 2 (MCM2), minichromosome maintenance complex component 2 (Mcm2), minichromosome maintenance complex component 2 L homeolog (mcm2.L), AA959861, AW476101, bm28, BM28, cb737, ccnl1, CCNL1, cdc19, cdcl1, CDCL1, CG7538, chunp6905, D3S3194, dMCM2, Dmel\\CG7538, DmeMCM2, DmMCM2, DmMcm2, l(3)rL074, MCM2, McM2, MCM2-7, MCM2_DROME, MCM7, Mcmd2, mitotin, MITOTIN, mKIAA0030, PCR3, XMcm2Protein level used designations for MCM2
- CG7538-PA
- Mcm2-PA
- minichromosome maintenance 2
- DNA replication licensing factor mcm2
- MCM2 minichromosome maintenance deficient 2, mitotin
- minichromosome maintenance protein 2
- DNA replication licensing factor MCM2
- cell devision cycle-like 1
- cyclin-like 1
- minichromosome maintenance deficient 2 (mitotin)
- minichromosome maintenance protein 2 homolog
- nuclear protein BM28
- minichromosome maintenance deficient 2 mitotin
- BM28-homolog
- p112
- xMCM2
- minichromosome maintenance complex component 7
- mini chromosome maintenance deficient 2
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