MCM10 Products
(Minichromosome Maintenance Deficient 10 (MCM10))
Categories
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured MCM10 Categories
MCM10 Antibodies
High quality antibodies with extensive validation data.
MCM10 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCM10 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN6263157
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN949450
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IF
Validations
- (1)
Cat. No.
ABIN7261385
Quantity
200 μL
Datasheet
Datasheet
Recommended MCM10 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6211737
Quantity
96 tests
Datasheet
Datasheet
Recommended MCM10 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310546
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093779
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134892
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MCM10 products
: "Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication." in: PLoS ONE, Vol. 10, Issue 10, pp. e0140645, (2015) (PubMed).: "Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 16, Issue 8, pp. 842-56, (2011) (PubMed).
: "Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication." in: Molecular biology of the cell, Vol. 18, Issue 10, pp. 4085-95, (2007) (PubMed).
: "The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism." in: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30631-44, (2006) (PubMed).
Synonyms and alternative names related to MCM10
Minichromosome maintenance 10 (Mcm10), minichromosome maintenance 10 replication initiation factor (MCM10), minichromosome maintenance 10 replication initiation factor (Mcm10), minichromosome maintenance 10 replication initiation factor L homeolog (mcm10.L), 2410041F14Rik, AU018508, C79164, C330019M07Rik, CG9241, CNA43, Dmel\\CG9241, DmMCM10, DNA43, mcm10, Scim19, xmcm10Protein level used designations for MCM10
- CG9241-PA
- Mcm10-PA
- sensitized chromosome inheritance modifier 19
- MCM10 minichromosome maintenance deficient 10
- homolog of yeast MCM10
- hsMCM10
- protein MCM10 homolog
- minichromosome maintenance deficient 10
- Mcm10p
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