MCFD2 Products
(Multiple Coagulation Factor Deficiency 2 (MCFD2))
Categories
This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1\; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D)\; a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010].
antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.
Featured MCFD2 Categories
MCFD2 Antibodies
High quality antibodies with extensive validation data.
MCFD2 ELISA Kits
Reliable ELISA kits for a wide range of species.
MCFD2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCFD2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), RNAi
Validations
- (6)
Cat. No.
ABIN566639
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
Cat. No.
ABIN4911821
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
Cat. No.
ABIN1327026
Quantity
100 μg
Datasheet
Datasheet
Recommended MCFD2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968701
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968702
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1143338
Quantity
96 tests
Datasheet
Datasheet
Recommended MCFD2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666930
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310538
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130495
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our MCFD2 products
: "Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex." in: Traffic (Copenhagen, Denmark), Vol. 7, Issue 11, pp. 1473-81, (2006) (PubMed).: "Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency of factor V and VIII." in: American journal of hematology, Vol. 79, Issue 4, pp. 262-6, (2005) (PubMed).
: "LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway." in: The Journal of biological chemistry, Vol. 280, Issue 27, pp. 25881-6, (2005) (PubMed).
Synonyms and alternative names related to MCFD2
multiple coagulation factor deficiency 2 (MCFD2), multiple coagulation factor deficiency 2 (mcfd2), multiple coagulation factor deficiency 2 L homeolog (mcfd2.L), multiple coagulation factor deficiency 2 (Mcfd2), 1810021C21Rik, DKFZp469B098, F5F8D, F5f8d, F5F8D2, hm:zeh1186, LMAN1IP, Lman1ip, MCFD2, SDNSF, Sdnsf, wu:fc23b10, wu:fd50d08, zgc:103713, zgc:109915Protein level used designations for MCFD2
- multiple coagulation factor deficiency 2
- multiple coagulation factor deficiency protein 2
- Multiple coagulation factor deficiency protein 2 homolog
- neural stem cell derived neuronal survival protein
- neural stem cell-derived neuronal survival protein
- multiple coagulation factor deficiency protein 2 homolog
- stem cell derived neuronal survival protein
You are here:
