MCC Products
(Mutated in Colorectal Cancers (MCC))
Categories
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured MCC Categories
MCC Antibodies
High quality antibodies with extensive validation data.
MCC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (4)
Cat. No.
ABIN950122
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, RNAi
Validations
- (4)
Cat. No.
ABIN561756
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7148294
Quantity
100 μg
Datasheet
Datasheet
Recommended MCC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310523
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310525
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3091956
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MCC products
: "'Default' generated neonatal regulatory T cells are hypomethylated at conserved non-coding sequence 2 and promote long-term cardiac allograft survival." in: Immunology, Vol. 143, Issue 4, pp. 618-30, (2014) (PubMed).: "CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway." in: Blood, Vol. 114, Issue 3, pp. 580-8, (2009) (PubMed).
: "Loss of heterozygosity of APC and MCC genes in oral squamous cell carcinomas in Taiwan." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 26, Issue 7, pp. 322-6, (1997) (PubMed).
: "MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase." in: The Journal of biological chemistry, Vol. 271, Issue 17, pp. 10341-6, (1996) (PubMed).
: "Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer." in: International journal of cancer. Journal international du cancer, Vol. 55, Issue 4, pp. 598-603, (1993) (PubMed).
: "MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer." in: Oncogene, Vol. 6, Issue 10, pp. 1881-6, (1991) (PubMed).
: "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers." in: Science (New York, N.Y.), Vol. 251, Issue 4999, pp. 1366-70, (1991) (PubMed).
Synonyms and alternative names related to MCC
mutated in colorectal cancers (MCC), mutated in colorectal cancers (mcc), mutated in colorectal cancers (Mcc), D18Ertd451e, E330037C19, MCC, mcc1, MCC1, RGD1561988Protein level used designations for MCC
- mutated in colorectal cancers
- colorectal mutant cancer protein
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