MCAM Products
(Melanoma Cell Adhesion Molecule (MCAM))
Categories
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
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Featured MCAM Categories
MCAM Antibodies
High quality antibodies with extensive validation data.
MCAM ELISA Kits
Reliable ELISA kits for a wide range of species.
MCAM Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MCAM Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, IHC, WB, ELISA
Validations
- (2)
- (7)
Cat. No.
ABIN1724844
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, WB, IF, ELISA
Validations
- (7)
Cat. No.
ABIN7147325
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, WB, IF
Validations
- (7)
Cat. No.
ABIN6143621
Quantity
100 μL
Datasheet
Datasheet
Recommended MCAM ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6962587
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (1)
Cat. No.
ABIN6960653
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960654
Quantity
96 tests
Datasheet
Datasheet
Recommended MCAM Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275297
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275301
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310514
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MCAM products
: "Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis." in: Frontiers in immunology, Vol. 11, pp. 1598, (2020) (PubMed).: "Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice." in: Redox biology, Vol. 24, pp. 101192, (2019) (PubMed).
: "The Role of MicroRNA-143-5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 536-546, (2018) (PubMed).
: "ImmunoPET Imaging of CD146 in Murine Models of Intrapulmonary Metastasis of Non-Small Cell Lung Cancer." in: Molecular pharmaceutics, Vol. 14, Issue 10, pp. 3239-3247, (2018) (PubMed).
: "The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis." in: Nature communications, Vol. 8, pp. 15279, (2018) (PubMed).
: "Sox10+adult stem cells contribute to biomaterial encapsulation and microvascularization." in: Scientific reports, Vol. 7, pp. 40295, (2017) (PubMed).
: "The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis." in: Oncotarget, Vol. 8, Issue 9, pp. 15520-15538, (2017) (PubMed).
: "Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis." in: Cell research, Vol. 27, Issue 3, pp. 352-372, (2017) (PubMed).
: "Exendin-4 promotes proliferation of adipose-derived stem cells through ERK and JNK signaling pathways." in: In vitro cellular & developmental biology. Animal, Vol. 52, Issue 5, pp. 598-606, (2016) (PubMed).
: "CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor." in: Oncogene, Vol. 35, Issue 40, pp. 5317-5327, (2016) (PubMed).
Synonyms and alternative names related to MCAM
melanoma cell adhesion molecule (MCAM), melanoma cell adhesion molecule (Mcam), melanoma cell adhesion molecule b (mcamb), 1-gicerin, AV025631, CD146, cd146, CD149, gicerin, id:ibd3512, mcam, MCAM, MUC18, Muc18, s-endo, s-gicerinProtein level used designations for MCAM
- Gicerin
- S-endo 1 endothelial-associated antigen
- cell surface glycoprotein MUC18
- cell surface glycoprotein P1H12
- melanoma adhesion molecule
- melanoma-associated antigen A32
- melanoma-associated antigen MUC18
- gicerin
- l-gicerin
- l-gicerin protein
- cell adhesion molecule
- HEMCAM
- melanoma cell adhesion molecule
- cell surface glycoprotein MUC18-like
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