MC1 Receptor Products
(Melanocortin 1 Receptor (MC1R))
Categories
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008].
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Featured MC1 Receptor Categories
MC1 Receptor Antibodies
High quality antibodies with extensive validation data.
MC1 Receptor ELISA Kits
Reliable ELISA kits for a wide range of species.
MC1 Receptor Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MC1 Receptor Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7159233
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN686287
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6259272
Quantity
100 μL
Datasheet
Datasheet
Recommended MC1 Receptor ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6233295
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6233294
Quantity
96 tests
Datasheet
Datasheet
Recommended MC1 Receptor Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310505
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Mammalian Cells
Validations
Cat. No.
ABIN7538382
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3099289
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our MC1 Receptor products
: "Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 4396467, (2018) (PubMed).: "Mechanistic Studies on the Use of Polygonum multiflorum for the Treatment of Hair Graying." in: BioMed research international, Vol. 2015, pp. 651048, (2016) (PubMed).
: "Increased corticotropin-releasing hormone (CRH) expression in cutaneous lupus lesions." in: Lupus, Vol. 24, Issue 8, pp. 854-61, (2015) (PubMed).
Synonyms and alternative names related to MC1 Receptor
melanocortin 1 receptor (MC1R), melanocortin 1 receptor (Mc1r), melanocortin 1 receptor (mc1r), melanocortin 1 receptor (mc1r_par1), melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R), CMM5, e, MC1-R, mc1r, MC1R, MSH-R, MSHR, Mshra, SHEP2, Tob, TUBB3Protein level used designations for MC1 Receptor
- MC1-R
- melanocyte-stimulating hormone receptor
- melanotropin receptor
- MSH-R
- extension recessive yellow
- melanocortin receptor 1
- melanocortin-1 receptor
- tobacco darkening
- BDF3
- alpha melanocyte stimulating hormone receptor
- melanocortin 1-receptor
- melanocyte stimulating hormone receptor
- melanocortin 1 receptor
- Melanotropin receptor
- Melanocortin receptor 1
- Melanocyte-stimulating hormone receptor
- tubulin, beta 3 class III
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