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MBD4 Products

(Methyl-CpG Binding Domain Protein 4 (MBD4))

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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].

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Featured MBD4 Categories

MBD4 Antibodies

High quality antibodies with extensive validation data.

MBD4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MBD4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (3)
  • (1)
Cat. No. ABIN1881532
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB
Validations
  • (2)
Cat. No. ABIN3044062
Quantity 100 μg
Datasheet Datasheet
Reactivity Guinea Pig, Human
Application WB, ChIP
Validations
  • (2)
Cat. No. ABIN2776028
Quantity 100 μL
Datasheet Datasheet

Recommended MBD4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6224403
Quantity 96 tests
Datasheet Datasheet

Recommended MBD4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123938
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310474
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310473
Quantity 25 μg
Datasheet Datasheet

Latest Publications for our MBD4 products

Kristensen, Nielsen, Jørgensen, Skakkebæk, Rajpert-De Meyts, Almstrup: "Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis." in: British journal of cancer, Vol. 110, Issue 3, pp. 668-78, (2014) (PubMed).

Arora, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Thyagarajan: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." in: Leukemia, Vol. 24, Issue 8, pp. 1470-5, (2010) (PubMed).

Thyagarajan, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Arora: "Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations." in: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Vol. 16, Issue 8, pp. 1084-9, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Ruddock-DCruz, Xue, Wilson, Heffernan, Prashadkumar, Cooney, Sanchez-Partida, French, Holland: "Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development." in: Molecular reproduction and development, Vol. 75, Issue 1, pp. 48-59, (2007) (PubMed).

Thatcher, Peddada, Yasui, Lasalle: "Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples." in: Human molecular genetics, Vol. 14, Issue 6, pp. 785-97, (2005) (PubMed).

Synonyms and alternative names related to MBD4

methyl-CpG binding domain 4, DNA glycosylase (MBD4), methyl-CpG binding domain protein 4 (Mbd4), methyl-CpG binding domain 4 DNA glycosylase (Mbd4), MED1, Med1

Protein level used designations for MBD4

  • 3,N(4)-ethenocytosine glycosylase
  • G/5-fluorouracil mismatch glycosylase with biphasic kinetics
  • G/T mismatch glycosylase
  • G/U mismatch glycosylase
  • methyl-CpG-binding domain protein 4
  • methyl-CpG-binding endonuclease 1
  • methyl-CpG-binding protein MBD4
  • mismatch-specific DNA N-glycosylase
  • putative methyl-CpG binding protein
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