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MBD1 Products

(Methyl-CpG Binding Domain Protein 1 (MBD1))

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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions\; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides\; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011].

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Featured MBD1 Categories

MBD1 Antibodies

High quality antibodies with extensive validation data.

MBD1 ELISA Kits

Reliable ELISA kits for a wide range of species.

MBD1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MBD1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (4)
Cat. No. ABIN517760
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN517761
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF, ICC
Validations
  • (3)
Cat. No. ABIN6263147
Quantity 100 μL
Datasheet Datasheet

Recommended MBD1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1142345
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1142346
Quantity 96 tests
Datasheet Datasheet

Recommended MBD1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1310462
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310463
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423543
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MBD1 products

Hendriks, Treffers, Verlaan-de Vries, Olsen, Vertegaal: "SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage." in: Cell reports, (2015) (PubMed).

Varshney, Vavrova-Anderson, Oler, Cowling, Cairns, White: "SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation." in: Nature communications, Vol. 6, pp. 6569, (2015) (PubMed).

Staples, Myers, Beveridge, Patil, Howard, Barone, Lee, Swanton, Howell, Maslen, Skehel, Boulton, Collis: "Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability." in: Journal of cell science, Vol. 127, Issue Pt 13, pp. 2910-9, (2014) (PubMed).

Waterfield, Khan, Cortez, Fan, Metzger, Greer, Fasano, Martinez-Llordella, Pollack, Erle, Su, Anderson: "The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance." in: Nature immunology, Vol. 15, Issue 3, pp. 258-65, (2014) (PubMed).

Staples, Myers, Beveridge, Patil, Lee, Swanton, Howell, Boulton, Collis: "The centriolar satellite protein Cep131 is important for genome stability." in: Journal of cell science, Vol. 125, Issue Pt 20, pp. 4770-9, (2012) (PubMed).

Jin, Kadam, Pfeifer: "Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine." in: Nucleic acids research, Vol. 38, Issue 11, pp. e125, (2010) (PubMed).

Zhao, Wu, Bu, Lu, Liang, Cao, Tong, Lu, Wu, Guo et al.: "Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive ..." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 1, pp. 142-53, (2009) (PubMed).

Kumar, Verma: "Methods in cancer epigenetics and epidemiology." in: Methods in molecular biology (Clifton, N.J.), Vol. 471, pp. 273-88, (2008) (PubMed).

Ruddock-DCruz, Xue, Wilson, Heffernan, Prashadkumar, Cooney, Sanchez-Partida, French, Holland: "Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development." in: Molecular reproduction and development, Vol. 75, Issue 1, pp. 48-59, (2007) (PubMed).

Villa, Pasini, Gutierrez, Morey, Occhionorelli, Viré, Nomdedeu, Jenuwein, Pelicci, Minucci, Fuks, Helin, Di Croce: "Role of the polycomb repressive complex 2 in acute promyelocytic leukemia." in: Cancer cell, Vol. 11, Issue 6, pp. 513-25, (2007) (PubMed).

Synonyms and alternative names related to MBD1

methyl-CpG binding domain protein 1 (MBD1), methyl-CpG binding domain protein 1 (Mbd1), CCDC11, CXXC3, Cxxc3, PCM1, RFT

Protein level used designations for MBD1

  • CXXC-type zinc finger protein 3
  • methyl-CpG binding domain protein 1 isoform PCM1
  • methyl-CpG-binding domain protein 1
  • protein containing methyl-CpG-binding domain 1
  • the regulator of fibroblast growth factor 2 (FGF-2) transcription
  • methyl-CpG-binding protein MBD1
  • coiled-coil domain containing 11
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