MBD1 Products
(Methyl-CpG Binding Domain Protein 1 (MBD1))
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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions\; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides\; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011].
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MBD1 Antibodies
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MBD1 ELISA Kits
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MBD1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MBD1 Antibodies
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ABIN517761
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Recommended MBD1 ELISA Kits
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Latest Publications for our MBD1 products
: "SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage." in: Cell reports, (2015) (PubMed).: "SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation." in: Nature communications, Vol. 6, pp. 6569, (2015) (PubMed).
: "Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability." in: Journal of cell science, Vol. 127, Issue Pt 13, pp. 2910-9, (2014) (PubMed).
: "The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance." in: Nature immunology, Vol. 15, Issue 3, pp. 258-65, (2014) (PubMed).
: "The centriolar satellite protein Cep131 is important for genome stability." in: Journal of cell science, Vol. 125, Issue Pt 20, pp. 4770-9, (2012) (PubMed).
: "Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine." in: Nucleic acids research, Vol. 38, Issue 11, pp. e125, (2010) (PubMed).
: "Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive ..." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 1, pp. 142-53, (2009) (PubMed).
: "Methods in cancer epigenetics and epidemiology." in: Methods in molecular biology (Clifton, N.J.), Vol. 471, pp. 273-88, (2008) (PubMed).
: "Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development." in: Molecular reproduction and development, Vol. 75, Issue 1, pp. 48-59, (2007) (PubMed).
: "Role of the polycomb repressive complex 2 in acute promyelocytic leukemia." in: Cancer cell, Vol. 11, Issue 6, pp. 513-25, (2007) (PubMed).
Synonyms and alternative names related to MBD1
methyl-CpG binding domain protein 1 (MBD1), methyl-CpG binding domain protein 1 (Mbd1), CCDC11, CXXC3, Cxxc3, PCM1, RFTProtein level used designations for MBD1
- CXXC-type zinc finger protein 3
- methyl-CpG binding domain protein 1 isoform PCM1
- methyl-CpG-binding domain protein 1
- protein containing methyl-CpG-binding domain 1
- the regulator of fibroblast growth factor 2 (FGF-2) transcription
- methyl-CpG-binding protein MBD1
- coiled-coil domain containing 11
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