MASP1 Products
(Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
Categories
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
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Featured MASP1 Categories
MASP1 Antibodies
High quality antibodies with extensive validation data.
MASP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
MASP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MASP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (6)
Cat. No.
ABIN7434299
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7434302
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (p), IHC (p)
Validations
- (2)
Cat. No.
ABIN733508
Quantity
100 μL
Datasheet
Datasheet
Recommended MASP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6957634
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957635
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968437
Quantity
96 tests
Datasheet
Datasheet
Recommended MASP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310414
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505079
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
Cat. No.
ABIN7454178
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our MASP1 products
: "Plasma proteome profiling of high-altitude polycythemia using TMT-based quantitative proteomics approach." in: Journal of proteomics, Vol. 194, pp. 60-69, (2020) (PubMed).: "AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in MASP1 Associated with Pulmonary Tuberculosis in an Indian Population." in: Frontiers in immunology, Vol. 9, pp. 242, (2019) (PubMed).
: "Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 2, (2017) (PubMed).
: "The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 8, pp. 3596-604, (2015) (PubMed).
: "Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype." in: The Journal of biological chemistry, Vol. 289, Issue 13, pp. 9113-20, (2014) (PubMed).
: "The biological functions of MBL-associated serine proteases (MASPs)." in: Immunobiology, Vol. 205, Issue 4-5, pp. 467-75, (2002) (PubMed).
: "Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter." in: International immunology, Vol. 14, Issue 10, pp. 1193-201, (2002) (PubMed).
: "Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G." in: International immunology, Vol. 15, Issue 1, pp. 109-17, (2002) (PubMed).
: "The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes." in: Immunobiology, Vol. 205, Issue 4-5, pp. 455-66, (2002) (PubMed).
: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, (2002) (PubMed).
Synonyms and alternative names related to MASP1
mannan-binding lectin serine peptidase 1 (Masp1), mannan binding lectin serine peptidase 1 (MASP1), 3MC1, AW048060, CCPII, Crarf, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRFProtein level used designations for MASP1
- MASP-1
- complement factor MASP-3
- complement-activating component of Ra-reactive factor
- mannan-binding lectin serine protease 1
- mannose-binding lectin-associated serine protease 1
- mannose-binding protein-associated serine protease
- ra-reactive factor serine protease p100
- raRF
- serine protease 5
- Ra-reactive factor serine protease p100
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