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MAPKAP Kinase 5 Products

(Mitogen-Activated Protein Kinase-Activated Protein Kinase 5 (MAPKAPK5))

Categories

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012].

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Featured MAPKAP Kinase 5 Categories

MAPKAP Kinase 5 Antibodies

High quality antibodies with extensive validation data.

MAPKAP Kinase 5 ELISA Kits

Reliable ELISA kits for a wide range of species.

MAPKAP Kinase 5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAPKAP Kinase 5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN710546
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6255616
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN389587
Quantity 400 μL
Datasheet Datasheet

Recommended MAPKAP Kinase 5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380844
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended MAPKAP Kinase 5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
Cat. No. ABIN1310330
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310332
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7317049
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our MAPKAP Kinase 5 products

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Daily, Monks, Leggas, Moscow: "Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition." in: Toxicon : official journal of the International Society on Toxinology, Vol. 55, Issue 4, pp. 827-37, (2010) (PubMed).

Marasa, Srikantan, Masuda, Abdelmohsen, Kuwano, Yang, Martindale, Rinker-Schaeffer, Gorospe: "Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs." in: Science signaling, Vol. 2, Issue 94, pp. ra69, (2009) (PubMed).

Sun, Yoshizuka, New, Moser, Li, Liao, Xie, Chen, Deng, Yamout, Dong, Frangou, Yates, Wright, Han: "PRAK is essential for ras-induced senescence and tumor suppression." in: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).

Paliga, Natale, Watson: "p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 97, Issue 8, pp. 629-40, (2005) (PubMed).

Wijtten, Prak, Lemme, Langhout: "Effect of different dietary ideal protein concentrations on broiler performance." in: British poultry science, Vol. 45, Issue 4, pp. 504-11, (2004) (PubMed).

New, Jiang, Han: "Regulation of PRAK subcellular location by p38 MAP kinases." in: Molecular biology of the cell, Vol. 14, Issue 6, pp. 2603-16, (2003) (PubMed).

Sudo, Maruyama, Osada: "p62 functions as a p38 MAP kinase regulator." in: Biochemical and biophysical research communications, Vol. 269, Issue 2, pp. 521-5, (2000) (PubMed).

Synonyms and alternative names related to MAPKAP Kinase 5

mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), mitogen-activated protein kinase-activated protein kinase 5 (mapkapk5), MAP kinase-activated protein kinase 5 (Mapkapk5), mitogen-activated protein kinase-activated protein kinase 5 (Mapkapk5), MAPKAP-K5, MAPKAPK5, MK-5, MK5, PRAK

Protein level used designations for MAPKAP Kinase 5

  • mitogen-activated protein kinase-activated protein kinase 5
  • MAP kinase-activated protein kinase 5
  • MAP kinase-activated protein kinase 5-like
  • MAPK-activated protein kinase 5
  • MAPKAP kinase 5
  • MAPKAPK-5
  • p38-regulated/activated protein kinase
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