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MAPK6 Products

(Mitogen-Activated Protein Kinase 6 (MAPK6))

Categories

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008].

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Featured MAPK6 Categories

MAPK6 Antibodies

High quality antibodies with extensive validation data.

MAPK6 ELISA Kits

Reliable ELISA kits for a wide range of species.

MAPK6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAPK6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (6)
Cat. No. ABIN519220
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, RNAi
Validations
  • (6)
Cat. No. ABIN562409
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (2)
  • (3)
Cat. No. ABIN969115
Quantity 100 μL
Datasheet Datasheet

Recommended MAPK6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN1114844
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380412
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended MAPK6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310298
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310296
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7421311
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MAPK6 products

Wang, Kong, Lin, Li, Izumiya, Ding, Zhang, Hu, Yang, Gao, Lam, Li: "A versatile nanoplatform for synergistic combination therapy to treat human esophageal cancer." in: Acta pharmacologica Sinica, Vol. 38, Issue 6, pp. 931-942, (2018) (PubMed).

Perander, Al-Mahdi, Jensen, Nunn, Kildalsen, Johansen, Gabrielsen, Keyse, Seternes: "Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2." in: Scientific reports, Vol. 7, pp. 43471, (2017) (PubMed).

De la Mota-Peynado, Chernoff, Beeser: "Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity." in: The Journal of biological chemistry, Vol. 286, Issue 15, pp. 13603-11, (2011) (PubMed).

Klinger, Turgeon, Lévesque, Wood, Aagaard-Tillery, Meloche: "Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 39, pp. 16710-5, (2009) (PubMed).

Déléris, Rousseau, Coulombe, Rodier, Tanguay, Meloche: "Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5." in: Journal of cellular physiology, Vol. 217, Issue 3, pp. 778-88, (2008) (PubMed).

Purcell, Wilkins, York, Saba-El-Leil, Meloche, Robbins, Molkentin: "Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 35, pp. 14074-9, (2007) (PubMed).

Clark, Hynes: "Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14814-8, (1996) (PubMed).

Milasincic, Calera, Farmer, Pilch: "Stimulation of C2C12 myoblast growth by basic fibroblast growth factor and insulin-like growth factor 1 can occur via mitogen-activated protein kinase-dependent and -independent pathways." in: Molecular and cellular biology, Vol. 16, Issue 11, pp. 5964-73, (1996) (PubMed).

Sauma, Friedman: "Increased expression of protein kinase C beta activates ERK3." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11422-6, (1996) (PubMed).

Cobb, Goldsmith: "How MAP kinases are regulated." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 14843-6, (1995) (PubMed).

Synonyms and alternative names related to MAPK6

mitogen-activated protein kinase 6 (MAPK6), mitogen-activated protein kinase 6 (Mapk6), MAP kinase 6 (MPK6), mitogen-activated protein kinase 6 (mapk6), 2610021I23Rik, ATMAPK6, ATMPK6, D130053K17Rik, ERK3, Erk3, erk3, F18O19.10, HsT17250, Mapk4, MAPK6, Mapk63, MAP KINASE 6, MAP kinase 6, p97MAPK, p97mapk, Prkm4, PRKM6, Prkm6, si:ch211-235f12.1, SUSERK3

Protein level used designations for MAPK6

  • ERK-3
  • MAP kinase 6
  • MAP kinase isoform p97
  • MAPK 6
  • extracellular signal-regulated kinase 3
  • extracellular signal-regulated kinase, p97
  • p97-MAPK
  • protein kinase, mitogen-activated 5
  • protein kinase, mitogen-activated 6
  • p55-MAPK
  • Erk-3 related
  • mitogen activated protein kinase 4
  • mitogen activated protein kinase 6
  • protein kinase, mitogen activated kinase 4
  • extracellular related kinase 3
  • mitogen-activated protein kinase 6
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