MAPK10 Products
(Mitogen-Activated Protein Kinase 10 (MAPK10))
Categories
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured MAPK10 Categories
MAPK10 Antibodies
High quality antibodies with extensive validation data.
MAPK10 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAPK10 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
Cat. No.
ABIN5542487
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN3022948
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (3)
Cat. No.
ABIN7429106
Quantity
100 μL
Datasheet
Datasheet
Recommended MAPK10 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6213165
Quantity
96 tests
Datasheet
Datasheet
Recommended MAPK10 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310260
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1783176
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508978
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MAPK10 products
: "EphrinB2 controls vessel pruning through STAT1-JNK3 signalling." in: Nature communications, Vol. 6, pp. 6576, (2015) (PubMed).: "JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis." in: PLoS ONE, Vol. 9, Issue 1, pp. e87067, (2014) (PubMed).
: "Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin." in: Molecular biology of the cell, Vol. 19, Issue 10, pp. 4201-12, (2008) (PubMed).
: "The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells." in: Journal of leukocyte biology, Vol. 73, Issue 5, pp. 682-8, (2003) (PubMed).
: "Role of mitogen- and stress-activated kinases in ischemic injury." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 22, Issue 6, pp. 631-47, (2002) (PubMed).
: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, (2002) (PubMed).
: "Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3." in: The EMBO journal, Vol. 21, Issue 3, pp. 324-33, (2002) (PubMed).
: "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes." in: Blood, Vol. 100, Issue 7, pp. 2546-53, (2002) (PubMed).
: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).
: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, (2000) (PubMed).
Synonyms and alternative names related to MAPK10
mitogen-activated protein kinase 8 S homeolog (mapk8.S), mitogen-activated protein kinase 10 (MAPK10), mitogen-activated protein kinase 10 (mapk10), mitogen activated protein kinase 10 (Mapk10), mitogen-activated protein kinase 10 (Mapk10), MAP kinase 10 (MPK10), ATMPK10, C230008H04Rik, DKFZp459H0638, Jnk3, JNK3, JNK3A, JNK3B1, JNK3B2, MAPK10, MAP kinase 10, p54bSAPK, p493F12, PRKM10, SAPb, SAPK(beta), SAPK1b, SAPKC, Serk2, zgc:123234Protein level used designations for MAPK10
- mitogen-activated protein kinase 10
- jnk3
- MAP kinase 10
- MAPK 10
- SAPK-beta
- Stress activated protein kinase beta
- c-Jun N-terminal kinase 3
- p54-beta
- stress-activated protein kinase JNK3
- JNK3 alpha protein kinase
- MAP kinase p49 3F12
- stress activated protein kinase beta
- stress-activated protein kinase 1b
- JNK3 beta1 protein kinase
- JNK3 beta2 protein kinase
- SAPK/Erk/kinase 2
- mitogen activated protein kinase 10
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