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MAP4K6 Products

(Misshapen-Like Kinase 1 (MINK1))
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].

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Featured MAP4K6 Categories

MAP4K6 Antibodies

High quality antibodies with extensive validation data.

MAP4K6 ELISA Kits

Reliable ELISA kits for a wide range of species.

MAP4K6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAP4K6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Bat, Cow, Horse, Human, Monkey, Mouse, Pig, Rat
Application IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN1049061
Quantity 50 μg
Datasheet Datasheet
Reactivity Bat, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat
Application ELISA, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN213551
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7187298
Quantity 100 μg
Datasheet Datasheet

Recommended MAP4K6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648287
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1142650
Quantity 96 tests
Datasheet Datasheet

Recommended MAP4K6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509014
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3093824
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3137332
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MAP4K6 products

Yu, Hu, Sheng, Fu, Wang, Chen, Pan, Zhang, Wu, Sun, Dai, Lu, Ouyang: "Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFβ signaling." in: Osteoarthritis and cartilage, Vol. 28, Issue 1, pp. 112-121, (2020) (PubMed).

Fu, Xu, Qiu, Jin, Xu, Dong, Wang, Ke, Hu, Cao, Wang, Cantor, Gao, Lu: "Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1." in: The Journal of experimental medicine, Vol. 214, Issue 5, pp. 1453-1469, (2017) (PubMed).

Larhammar, Huntwork-Rodriguez, Rudhard, Sengupta-Ghosh, Lewcock: "The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 37, Issue 46, pp. 11074-11084, (2017) (PubMed).

Gloerich, ten Klooster, Vliem, Koorman, Zwartkruis, Clevers, Bos: "Rap2A links intestinal cell polarity to brush border formation." in: Nature cell biology, Vol. 14, Issue 8, pp. 793-801, (2012) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Dan, Watanabe, Kobayashi, Yamashita-Suzuki, Fukagaya, Kajikawa, Kimura, Nakashima, Matsumoto, Ninomiya-Tsuji, Kusumi: "Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development." in: FEBS letters, Vol. 469, Issue 1, pp. 19-23, (2000) (PubMed).

Synonyms and alternative names related to MAP4K6

misshapen like kinase 1 (MINK1), misshapen-like kinase 1 (Mink1), misshapen-like kinase 1 (zebrafish) (Mink1), B55, hMINK, hMINKbeta, MAP4K6, Map4k6, MEKKK 6, MINK, MINK1, RP23-122P1.6, YSK2, Ysk2, ZC3

Protein level used designations for MAP4K6

  • misshapen-like kinase 1 (zebrafish)
  • misshapen/NIK-related kinase
  • GCK family kinase MINK
  • MAPK/ERK kinase kinase kinase 6
  • MEK kinase kinase 6
  • MEKKK 6
  • mitogen-activated protein kinase kinase kinase kinase 6
  • serine/threonine protein kinase
  • GCK family kinase MiNK
  • GCK family kinase
  • Misshapen/NIKs-related kinase
  • Yeast Sps1/Ste20-related kinase 2
  • misshapen-like kinase 1
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