MAP3K8 Products
(Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
Categories
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].
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Featured MAP3K8 Categories
MAP3K8 Antibodies
High quality antibodies with extensive validation data.
MAP3K8 ELISA Kits
Reliable ELISA kits for a wide range of species.
MAP3K8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP3K8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (5)
Cat. No.
ABIN701275
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7160057
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6255657
Quantity
100 μL
Datasheet
Datasheet
Recommended MAP3K8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380113
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended MAP3K8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310239
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310237
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7317083
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our MAP3K8 products
: "TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth." in: PLoS ONE, Vol. 6, Issue 1, pp. e16205, (2011) (PubMed).: "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis." in: Diabetes, Vol. 59, Issue 1, pp. 61-70, (2009) (PubMed).
: "Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7984-93, (2009) (PubMed).
: "Tpl2 is a key mediator of arsenite-induced signal transduction." in: Cancer research, Vol. 69, Issue 20, pp. 8043-9, (2009) (PubMed).
: "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction." in: Immunity, Vol. 29, Issue 1, pp. 12-20, (2008) (PubMed).
: "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31379-86, (2000) (PubMed).
Synonyms and alternative names related to MAP3K8
mitogen-activated protein kinase kinase kinase 8 (MAP3K8), mitogen-activated protein kinase kinase kinase 8 (map3k8), mitogen-activated protein kinase kinase kinase 8 (Map3k8), c-COT, COT, Cot, Cot/Tpl2, D17TPL2, EST, Est, ESTF, Estf, MAP3K8, MEKK8, Tpl-2, TPL2, Tpl2Protein level used designations for MAP3K8
- mitogen-activated protein kinase kinase kinase 8
- Ewing sarcoma transformant
- cot (cancer Osaka thyroid) oncogene
- proto-oncogene c-Cot
- proto-oncogene serine/threoine protein kinase
- tumor progression locus 2
- COT proto-oncogene serine/threonine-protein kinase
- cancer Osaka thyroid oncogene
- cancer Osaka thyroid, oncogene
- mitogen activated protein kinase kinase kinase 8
- serine/threonine-protein kinase cot
- serine/threonine kinase (Tpl-2)
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