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MAP3K4 Proteins

(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

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MAP3K4 Protein (AA 1201-1300) (GST tag) (ABIN1310218)

MAP3K4 Origin: Human Host: Wheat germ Recombinant WB, AP, AA, ELISA

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recommended

MAP3K4 Protein (ABIN2750508)

MAP3K4 Origin: Human, Mouse, Rat Host: Escherichia coli (E. coli) Recombinant WB, PC

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MAP3K4 Proteins by Origin

Find MAP3K4 Proteins for a variety of species such as anti-Human MAP3K4, anti-Mouse MAP3K4, anti-Rat MAP3K4. The species listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 Proteins by Source

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MAP3K4 Proteins by Protein Type

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MAP3K4 Proteins by Application

Find MAP3K4 Proteins validated for a specific application such as WB, AP, AA, ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular MAP3K4 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

MAP3K4 Protein (AA 1201-1300) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1310218

Quantity 10 μg

Datasheet Datasheet

MAP3K4 Protein

Reactivity Human, Mouse, Rat

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN2750508

Quantity 5 applications

Datasheet Datasheet

Aliases for MAP3K4 Proteins

mitogen activated protein kinase kinase kinase 4 (Map3k4) Proteins
mitogen-activated protein kinase kinase kinase 4 (MAP3K4) Proteins
mitogen-activated protein kinase kinase kinase 4 (Map3k4) Proteins
D17Rp17 Proteins
D17Rp17e Proteins
MAPKKK4 Proteins
Mek4b Proteins
MEKK4 Proteins
MEKK 4 Proteins
Mekk4 Proteins
mKIAA0213 Proteins
MTK1 Proteins
PRO0412 Proteins
RP17 Proteins
Rp17a Proteins
Tas Proteins

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MAP3K4 Proteins by Origin

MAP3K4 Proteins by Source

MAP3K4 Proteins by Protein Type

MAP3K4 Proteins by Application

Popular MAP3K4 Proteins

Aliases for MAP3K4 Proteins

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