MAP3K4 Products
(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
Categories
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured MAP3K4 Categories
MAP3K4 Antibodies
High quality antibodies with extensive validation data.
MAP3K4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP3K4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN561801
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC, WB
Validations
- (4)
Cat. No.
ABIN7268654
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, PLA
Validations
- (3)
Cat. No.
ABIN561800
Quantity
100 μg
Datasheet
Datasheet
Recommended MAP3K4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6219424
Quantity
96 tests
Datasheet
Datasheet
Recommended MAP3K4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310218
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2750508
Quantity
5 applications
Datasheet
Datasheet
Latest Publications for our MAP3K4 products
: "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39366-73, (2004) (PubMed).: "Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37451-8, (2003) (PubMed).
: "Oligomerization of human Gadd45a protein." in: The Journal of biological chemistry, Vol. 276, Issue 42, pp. 39330-9, (2001) (PubMed).
Synonyms and alternative names related to MAP3K4
mitogen activated protein kinase kinase kinase 4 (Map3k4), mitogen-activated protein kinase kinase kinase 4 (MAP3K4), mitogen-activated protein kinase kinase kinase 4 (Map3k4), D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK4, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, TasProtein level used designations for MAP3K4
- mitogen-activated protein kinase kinase kinase 4
- MAP three kinase 1
- MAP/ERK kinase kinase 4
- MAPK/ERK kinase kinase 4
- MEK kinase 4
- MEKK 4
- SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
- dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)
- predicted protein of HQ0412
- T-associated sex reversal
- mitogen activated protein kinase kinase kinase 4
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