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MAP3K3 Products

(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))

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This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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Featured MAP3K3 Categories

MAP3K3 Antibodies

High quality antibodies with extensive validation data.

MAP3K3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAP3K3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN7268652
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (3)
Cat. No. ABIN7258882
Quantity 200 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, IHC (p)
Validations
  • (4)
Cat. No. ABIN3044008
Quantity 100 μg
Datasheet Datasheet

Recommended MAP3K3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310214
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310216
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509009
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our MAP3K3 products

Yang, Lai, Lai, Hsu, Kuo, Yu, Lin, Yang, Kuo, Wu, Chung: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).

Nakamura, Johnson: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).

Huang, Yang, Lin, Walker, Cheng, Liu, Su: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." in: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).

Uhlik, Abell, Johnson, Sun, Cuevas, Lobel-Rice, Horne, DellAcqua, Johnson: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." in: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).

Ellinger-Ziegelbauer, Brown, Kelly, Siebenlist et al.: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).

Synonyms and alternative names related to MAP3K3

mitogen activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (MAP3K3), mitogen-activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (map3k3), AW548911, MAPKKK3, MEKK3, Mekk3, mKIAA4031

Protein level used designations for MAP3K3

  • mitogen-activated protein kinase kinase kinase 3
  • MAP/ERK kinase kinase 3
  • MAPK/ERK kinase kinase 3
  • MEK kinase 3
  • MEKK 3
  • mitogen activated protein kinase kinase kinase 3
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