MAP3K3 Products
(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
Categories
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured MAP3K3 Categories
MAP3K3 Antibodies
High quality antibodies with extensive validation data.
MAP3K3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP3K3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7268652
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
Cat. No.
ABIN7258882
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3044008
Quantity
100 μg
Datasheet
Datasheet
Recommended MAP3K3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310214
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310216
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509009
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MAP3K3 products
: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).
: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." in: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).
: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." in: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).
: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).
Synonyms and alternative names related to MAP3K3
mitogen activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (MAP3K3), mitogen-activated protein kinase kinase kinase 3 (Map3k3), mitogen-activated protein kinase kinase kinase 3 (map3k3), AW548911, MAPKKK3, MEKK3, Mekk3, mKIAA4031Protein level used designations for MAP3K3
- mitogen-activated protein kinase kinase kinase 3
- MAP/ERK kinase kinase 3
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
- mitogen activated protein kinase kinase kinase 3
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