MAP2K5 Products
(Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))
Categories
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011].
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Featured MAP2K5 Categories
MAP2K5 Antibodies
High quality antibodies with extensive validation data.
MAP2K5 ELISA Kits
Reliable ELISA kits for a wide range of species.
MAP2K5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP2K5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
- (3)
- (1)
Cat. No.
ABIN754183
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (6)
Cat. No.
ABIN562429
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN562433
Quantity
100 μg
Datasheet
Datasheet
Recommended MAP2K5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968651
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1130739
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1130740
Quantity
96 tests
Datasheet
Datasheet
Recommended MAP2K5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
- (1)
Cat. No.
ABIN1310183
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310185
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509005
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MAP2K5 products
: "Melittin inhibits proliferation, migration and invasion of bladder cancer cells by regulating key genes based on bioinformatics and experimental assays." in: Journal of cellular and molecular medicine, Vol. 24, Issue 1, pp. 655-670, (2021) (PubMed).: "MicroRNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling." in: Scientific reports, Vol. 4, pp. 3819, (2014) (PubMed).
: "Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells." in: International journal of biological sciences, Vol. 10, Issue 2, pp. 171-80, (2014) (PubMed).
: "Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1." in: The EMBO journal, Vol. 33, Issue 16, pp. 1784-801, (2014) (PubMed).
: "G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR)." in: The Journal of biological chemistry, Vol. 285, Issue 18, pp. 13480-9, (2010) (PubMed).
: "Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction." in: Circulation research, Vol. 102, Issue 11, pp. 1416-25, (2008) (PubMed).
: "Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation." in: The Journal of biological chemistry, Vol. 279, Issue 2, pp. 1506-12, (2004) (PubMed).
: "MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation." in: Journal of cell science, Vol. 117, Issue Pt 9, pp. 1773-84, (2004) (PubMed).
: "MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion." in: Oncogene, Vol. 22, Issue 9, pp. 1381-9, (2003) (PubMed).
Synonyms and alternative names related to MAP2K5
mitogen activated protein kinase kinase 5 (Map2k5), mitogen-activated protein kinase kinase 5 (MAP2K5), mitogen-activated protein kinase kinase 5 (Map2k5), mitogen-activated protein kinase kinase 5 (map2k5), mitogen-activated protein kinase kinase 5 L homeolog (map2k5.L), MAP kinase kinase 5 (MKK5), AI324775, AI428457, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, ATMAP2K_ALPHA, ATMEK5, ATMKK5, fb73f02, HsT17454, MAP2K_A, MAP KINASE KINASE 5, MAP kinase kinase 5, MAPKK5, Mapkk5, Mek5, MEK5, PRKMK5, Prkmk5, wu:fb73f02, zgc:172137Protein level used designations for MAP2K5
- MAP kinase kinase 5
- MAPK/ERK kinase 5
- MAPKK 5
- MEK 5
- dual specificity mitogen-activated protein kinase kinase 5
- mitogen-activated protein kinase kinase 5
- MAP kinase kinase MEK5b
- MAPK/ERK kinese 5
- mitogen activated protein kinase kinase 5
- MEK5
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