MAP2K3 Products
(Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
Categories
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].
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Featured MAP2K3 Categories
MAP2K3 Antibodies
High quality antibodies with extensive validation data.
MAP2K3 ELISA Kits
Reliable ELISA kits for a wide range of species.
MAP2K3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAP2K3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (7)
Cat. No.
ABIN6143484
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA, ICC, FACS
Validations
- (9)
Cat. No.
ABIN5542528
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Mouse
Application
WB, IHC, IF, IHC (p)
Validations
- (9)
Cat. No.
ABIN1499401
Quantity
100 μL
Datasheet
Datasheet
Recommended MAP2K3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Cell ELISA
Validations
Cat. No.
ABIN4881290
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380776
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN2748359
Quantity
96 tests
Datasheet
Datasheet
Recommended MAP2K3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124000
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310177
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN6386730
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our MAP2K3 products
: "Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 768-781, (2018) (PubMed).: "MAPK kinase 10.2 promotes disease resistance and drought tolerance by activating different MAPKs in rice." in: The Plant journal : for cell and molecular biology, Vol. 92, Issue 4, pp. 557-570, (2018) (PubMed).
: "MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3." in: BMC cancer, Vol. 13, pp. 469, (2013) (PubMed).
: "MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation." in: Human molecular genetics, Vol. 22, Issue 21, pp. 4438-49, (2013) (PubMed).
: "MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival." in: Molecular cancer therapeutics, Vol. 6, Issue 4, pp. 1212-22, (2007) (PubMed).
: "Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4217-27, (2007) (PubMed).
: "The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling." in: The Journal of biological chemistry, Vol. 280, Issue 51, pp. 42097-105, (2005) (PubMed).
: "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase ..." in: Molecular biology of the cell, Vol. 14, Issue 2, pp. 529-44, (2003) (PubMed).
: "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38." in: Oncogene, Vol. 22, Issue 40, pp. 6129-41, (2003) (PubMed).
Synonyms and alternative names related to MAP2K3
mitogen-activated protein kinase kinase 3 (MAP2K3), mitogen-activated protein kinase kinase 3 (Map2k3), mitogen activated protein kinase kinase 3 (Map2k3), MAP kinase activator XMEK3 (map2k3), AW212142, MAPKK3, MEK3, MKK3, Mkk3, mMKK3b, PRKMK3, Prkmk3, SAPKK-2, SAPKK2Protein level used designations for MAP2K3
- MAP kinase kinase 3
- MAPK/ERK kinase 3
- MAPKK 3
- MEK 3
- SAPK kinase 2
- dual specificity mitogen-activated protein kinase kinase 3
- stress-activated protein kinase kinase 2
- mitogen activated protein kinase kinase 3
- protein kinase, mitogen-activated, kinase 3
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