MANF Products
(Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
Categories
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010].
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Featured MANF Categories
MANF Antibodies
High quality antibodies with extensive validation data.
MANF ELISA Kits
Reliable ELISA kits for a wide range of species.
MANF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MANF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (7)
Cat. No.
ABIN6143461
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7426499
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, IHC (p)
Validations
- (3)
Cat. No.
ABIN6990751
Quantity
0.1 mg
Datasheet
Datasheet
Recommended MANF ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6957758
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957759
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957760
Quantity
96 tests
Datasheet
Datasheet
Recommended MANF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN5509524
Quantity
40 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123914
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345666
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MANF products
: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).: "Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice." in: Neurobiology of disease, Vol. 134, pp. 104696, (2020) (PubMed).
: "MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System." in: eNeuro, Vol. 7, Issue 1, (2020) (PubMed).
: "MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex." in: eNeuro, Vol. 4, Issue 5, (2018) (PubMed).
: "Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance." in: Endocrine journal, Vol. 64, Issue 4, pp. 403-410, (2017) (PubMed).
: "Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling." in: The Journal of steroid biochemistry and molecular biology, Vol. 171, pp. 94-109, (2017) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Molecular effects of doxycycline treatment on pterygium as revealed by massive transcriptome sequencing." in: PLoS ONE, Vol. 7, Issue 6, pp. e39359, (2012) (PubMed).
: "MANF regulates dopaminergic neuron development in larval zebrafish." in: Developmental biology, Vol. 370, Issue 2, pp. 237-49, (2012) (PubMed).
: "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." in: Nature, Vol. 448, Issue 7149, pp. 73-7, (2007) (PubMed).
Synonyms and alternative names related to MANF
mesencephalic astrocyte derived neurotrophic factor (MANF), mesencephalic astrocyte-derived neurotrophic factor (Manf), RNA binding motif protein 15B (RBM15B), Mesencephalic astrocyte-derived neurotrophic factor (Manf), mesencephalic astrocyte-derived neurotrophic factor (manf), mesencephalic astrocyte derived neurotrophic factor (Manf), mesencephalic astrocyte-derived neurotrophic factor S homeolog (manf.S), 3230402M22Rik, AA407711, AA408789, AA673178, anon-EST:ParkEST188, ARMET, Armet, armet, ARP, arp, ARP-like, CG7013, D18Mgi17, D17914, Dmel\\CG7013, DmMANF, im:6909481, MANF, manf, RBM15B, zgc:153327Protein level used designations for MANF
- arginine-rich, mutated in early stage tumors
- arginine-rich protein
- mesencephalic astrocyte-derived neurotrophic factor
- RNA binding motif protein 15B
- chromosome 3p21.1 gene sequence
- CG7013-PA
- Manf-PA
- ARP-like
- LOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor
- mesencephalic astrocyte-derived neurotrophic factor S homeolog
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