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MAFA Products

(Transcription Factor MafA (MAFA))

Categories

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS\; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008].

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Featured MAFA Categories

MAFA Antibodies

High quality antibodies with extensive validation data.

MAFA Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAFA Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN567058
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF (p), IHC (p)
Validations
  • (1)
Cat. No. ABIN729898
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN653391
Quantity 400 μL
Datasheet Datasheet

Recommended MAFA Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310007
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3083372
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3125943
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MAFA products

Wilson, Spaeth, Karp, Stocks, Hoopes, Stein, Moore: "B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib." in: JCI insight, Vol. 5, (2019) (PubMed).

Spaeth, Liu, Peters, Guo, Osipovich, Mohammadi, Roy, Bhushan, Magnuson, Hebrok, Wright, Stein: "The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function." in: Diabetes, (2019) (PubMed).

Wade, Liu, Bethea, Toren, Tse, Hunter: "LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function." in: The Journal of biological chemistry, Vol. 294, Issue 31, pp. 11728-11740, (2019) (PubMed).

Jaafar, Tran, Shah, Sun, Valdearcos, Marchetti, Masini, Swisa, Giacometti, Bernal-Mizrachi, Matveyenko, Hebrok, Dor, Rutter, Koliwad, Bhushan: "mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes." in: The Journal of clinical investigation, Vol. 130, (2019) (PubMed).

Wei, Yoshihara, He, Hah, Fan, Pinto, Huddy, Wang, Ross, Estepa, Dai, Ding, Sherman, Fang, Zhao, Liddle, Atkins, Yu, Downes, Evans: "Vitamin D Switches BAF Complexes to Protect β Cells." in: Cell, Vol. 173, Issue 5, pp. 1135-1149.e15, (2018) (PubMed).

Sweeney, Bikoff, Gabitto, Brenner-Morton, Baek, Yang, Tabak, Dasen, Kintner, Jessell: "Origin and Segmental Diversity of Spinal Inhibitory Interneurons." in: Neuron, Vol. 97, Issue 2, pp. 341-355.e3, (2018) (PubMed).

Spaeth, Gupte, Perelis, Yang, Cyphert, Guo, Liu, Guo, Bass, Magnuson, Wright, Stein: "Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning." in: Diabetes, (2017) (PubMed).

Blanchet, Van de Velde, Matsumura, Hao, LeLay, Kaestner, Montminy: "Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance." in: Cell reports, Vol. 10, Issue 7, pp. 1149-57, (2015) (PubMed).

Scoville, Cyphert, Liao, Xu, Reynolds, Guo, Stein: "MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function." in: Diabetes, Vol. 64, Issue 11, pp. 3772-83, (2015) (PubMed).

Akai, Hosoda, Yoshino, Iwawaki: "Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 11, pp. 871-86, (2015) (PubMed).

Synonyms and alternative names related to MAFA

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) (Mafa), MAF bZIP transcription factor A (MAFA), MAF bZIP transcription factor A (Mafa), killer cell lectin-like receptor subfamily G, member 1 (Klrg1), v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A (mafa), v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa (mafaa), monocyte to macrophage differentiation-associated (Mmd), 2F1-Ag, hMafA, L-MAF, Maf, MAFA, MAFA-L, mafl, MAFL, RGD1562627, RIPE3b1, SMaf1

Protein level used designations for MAFA

  • Mafa homolog
  • V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
  • pancreatic beta-cell-specific transcriptional activator
  • transcription factor MafA
  • transcription factor RIPE3b1
  • v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A
  • killer cell lectin-like receptor subfamily G member 1
  • mast cell function-associated antigen 2F1
  • Transcription factor MafA
  • leucine zipper transcription factor
  • somite Maf1
  • v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L
  • bZIP transcription factor L-Maf
  • lens-specific Maf
  • macrophage/microglia activation-associated factor
  • monocyte to macrophage differentiation factor
  • monocyte to macrophage differentiation protein
  • progestin and adipoQ receptor family member XI
  • LOW QUALITY PROTEIN: transcription factor MafA
  • v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
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