MADD Products
(MAP-Kinase Activating Death Domain (MADD))
Categories
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured MADD Categories
MADD Antibodies
High quality antibodies with extensive validation data.
MADD ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended MADD Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7187234
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN3185435
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (fro)
Validations
- (1)
- (1)
Cat. No.
ABIN2475471
Quantity
0.1 mg
Datasheet
Datasheet
Recommended MADD ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648202
Quantity
96 tests
Datasheet
Datasheet
Recommended MADD Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422859
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7421455
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our MADD products
: "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors." in: The Journal of cell biology, Vol. 191, Issue 2, pp. 367-81, (2010) (PubMed).: "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 33111-7, (1998) (PubMed).
: "Persephin, a novel neurotrophic factor related to GDNF and neurturin. ..." in: Neuron, Vol. 20, Issue 2, pp. 245-53, (1998) (PubMed).
: "GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 10, pp. 5801-6, (1998) (PubMed).
Synonyms and alternative names related to MADD
MAP kinase activating death domain (MADD), MAP-kinase activating death domain (madd), MAP kinase activating death domain (madd), MAP-kinase activating death domain (Madd), 9630059K23Rik, DENN, IG20, MADD, MGC145371, RAB3GEPProtein level used designations for MADD
- MAP-kinase activating death domain
- MAP kinase-activating death domain protein
- MAP kinase-activating death domain protein-like
- Rab3 GDP/GTP exchange factor
- differentially expressed in normal and neoplastic cells
- insulinoma glucagonoma clone 20
- Rab3 GDP/GTP exchange protein
- Rab3 GEP
- insulinoma-glucagonoma protein 20
- rab3 GDP/GTP exchange factor
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