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MAD2 Products

(MAD2)

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Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008].

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Recommended MAD2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN3180719
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN6284562
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IP
Validations
Cat. No. ABIN7450431
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our MAD2 products

Tang, Yang, Liu: "Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression." in: Oncogene, Vol. 27, Issue 52, pp. 6635-45, (2008) (PubMed).

Synonyms and alternative names related to MAD2

MAD2 mitotic arrest deficient-like 1 (Mad2l1), MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1), MAX interactor 1, dimerization protein (MXI1), AA673185, bHLHc11, MAD2, MXD2, MXI

Protein level used designations for MAD2

  • MAD2 (mitotic arrest deficient, homolog)-like 1
  • MAD2-like protein 1
  • mitotic arrest deficient 2-like protein 1
  • mitotic spindle assembly checkpoint protein MAD2A
  • MAX dimerization protein 2
  • Max-related transcription factor
  • class C basic helix-loop-helix protein 11
  • max-interacting protein 1
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