LRRK2 Products
(Leucine-Rich Repeat Kinase 2 (LRRK2))
Categories
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
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Featured LRRK2 Categories
LRRK2 Antibodies
High quality antibodies with extensive validation data.
Recommended LRRK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
Cat. No.
ABIN7531848
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN391146
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (4)
- (3)
Cat. No.
ABIN1882109
Quantity
400 μL
Datasheet
Datasheet
Recommended LRRK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7399454
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7402172
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409104
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our LRRK2 products
: "LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease." in: Human molecular genetics, (2019) (PubMed).: "LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia." in: PLoS ONE, Vol. 14, Issue 1, pp. e0210248, (2019) (PubMed).
: "LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 38, Issue 7, pp. 1611-1621, (2019) (PubMed).
: "Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models." in: Cell metabolism, Vol. 30, Issue 6, pp. 1131-1140.e7, (2019) (PubMed).
: "Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations." in: Acta neuropathologica communications, Vol. 6, Issue 1, pp. 105, (2018) (PubMed).
: "Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1." in: Nature communications, Vol. 7, pp. 11792, (2016) (PubMed).
: "Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons." in: Journal of neuroinflammation, Vol. 13, Issue 1, pp. 295, (2016) (PubMed).
: "LRRK2 contributes to monocyte dysregulation in Parkinson's disease." in: Acta neuropathologica communications, Vol. 4, Issue 1, pp. 123, (2016) (PubMed).
: "Cerebral potential biomarkers discovery and metabolic pathways analysis of ?-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics ..." in: Journal of ethnopharmacology, Vol. 163, pp. 264-72, (2015) (PubMed).
: "Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways." in: Journal of neurochemistry, Vol. 131, Issue 2, pp. 239-50, (2015) (PubMed).
Synonyms and alternative names related to LRRK2
leucine-rich repeat kinase 2 (lrrk2), leucine rich repeat kinase 2 (LRRK2), leucine-rich repeat kinase 2 (Lrrk2), 4921513O20Rik, 9330188B09Rik, AURA17, AW561911, cI-46, D630001M17Rik, DARDARIN, Gm927, LRRK2, PARK8, RIPK7, ROCO2Protein level used designations for LRRK2
- leucine-rich repeat serine/threonine-protein kinase 2
- leucine-rich repeat kinase 2
- leucine-rich repeat serine/threonine-protein kinase 2-like
- augmented in rheumatoid arthritis 17
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