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LRP5 Products

(Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. [provided by RefSeq, Nov 2009].

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Featured LRP5 Categories

LRP5 Antibodies

High quality antibodies with extensive validation data.

LRP5 ELISA Kits

Reliable ELISA kits for a wide range of species.

LRP5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LRP5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
  • (4)
Cat. No. ABIN1513164
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (1)
  • (3)
Cat. No. ABIN185410
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (2)
  • (3)
Cat. No. ABIN969535
Quantity 100 μL
Datasheet Datasheet

Recommended LRP5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968355
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968354
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957541
Quantity 96 tests
Datasheet Datasheet

Recommended LRP5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275208
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (3)
Cat. No. ABIN6809855
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275209
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our LRP5 products

Pokharel, Mohanty, Mariasoosai, Miura, Maddison, Natesan, Bose: "Human beta defensin-3 mediated activation of β-catenin during human respiratory syncytial virus infection: interaction of HBD3 with LDL receptor-related protein 5." in: Frontiers in microbiology, Vol. 14, pp. 1186510, (2023) (PubMed).

Duvetorp, Olsen, Nyström, Skarstedt, Dienus, Mrowietz, Söderman, Seifert: "Expression of low-density lipoprotein-related receptors 5 and 6 (LRP5/6) in psoriasis skin." in: Experimental dermatology, Vol. 26, Issue 11, pp. 1033-1038, (2018) (PubMed).

Huang, Fantini, Merrill, Bagchi, Guzman, Raychaudhuri: "DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer." in: Cancer research, Vol. 77, Issue 23, pp. 6562-6575, (2018) (PubMed).

Dong, Li, Li, Ren, Fan, Weng: "MicroRNA-23a-3p inhibitor decreases osteonecrosis incidence in a rat model." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 9331-9336, (2018) (PubMed).

Fu, Wang, Wan, Lin, Chang, Han: "Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation." in: Journal of molecular histology, Vol. 47, Issue 5, pp. 455-66, (2017) (PubMed).

Wehmeyer, Frank, Beckmann, Böttcher, Cromme, König, Fennen, Held, Paruzel, Hartmann, Stratis, Korb-Pap, Kamradt, Kramer, van den Berg, Kneissel, Pap, Dankbar: "Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction." in: Science translational medicine, Vol. 8, Issue 330, pp. 330ra35, (2016) (PubMed).

Moon, Lee, Kim, Cho, Lee, Kim, Park, Cho, Lee, Oh: "Inhibition of Hepatitis C Virus in Mice by a Small Interfering RNA Targeting a Highly Conserved Sequence in Viral IRES Pseudoknot." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146710, (2016) (PubMed).

Wang, Chi, Yuan, Zhou, Yin, Zhang, Peng: "Astragaloside IV inhibits the up-regulation of Wnt/?-catenin signaling in rats with unilateral ureteral obstruction." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 5, pp. 1316-28, (2014) (PubMed).

Fei, Zhang, Huang, Xu, Zhu, Tai, Gong, Ma, Yao, Li, Zhao, Yang: "Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy." in: Molecular vision, Vol. 20, pp. 395-409, (2014) (PubMed).

Wiese, Gerlach, Popp, Matuszak, Mahapatro, Castiglione, Chakravortty, Willam, Hensel, Bogdan, Jantsch: "Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages." in: Infection and immunity, Vol. 80, Issue 4, pp. 1455-66, (2012) (PubMed).

Synonyms and alternative names related to LRP5

low-density lipoprotein receptor-related protein 5 (LOC100147353), LDL receptor related protein 5 (LRP5), LDL receptor related protein 5 L homeolog (lrp5.L), low density lipoprotein receptor-related protein 5 (lrp5), LDL receptor related protein 5 (lrp5), low density lipoprotein receptor-related protein 5 (Lrp5), LDL receptor related protein 5 (Lrp5), LDL receptor related protein 5 like (LRP5L), bmnd1, BMND1, evr1, EVR1, evr4, EVR4, hbm, HBM, lr3, LR3, LRP5, lrp5-A, LRP6, lrp7, LRP7, mKIAA4142, oppg, OPPG, ops, OPS, opta1, OPTA1, vbch2, VBCH2, Xlrp5

Protein level used designations for LRP5

  • Lipoprotein Receptor Related Protein 5
  • low density lipoprotein receptor-related protein 5
  • low-density lipoprotein receptor-related protein 5
  • low-density lipoprotein receptor-related protein 5-like
  • LRP-5
  • low density lipoprotein receptor-related protein 7
  • LRP-7
  • low-density lipoprotein receptor-related protein 7
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