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Lipin 1 Products

(Lipin 1 (LPIN1))
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012].

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Featured Lipin 1 Categories

Lipin 1 Antibodies

High quality antibodies with extensive validation data.

Lipin 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Lipin 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Lipin 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (3)
Cat. No. ABIN7436306
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7163118
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN672831
Quantity 100 μL
Datasheet Datasheet

Recommended Lipin 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957497
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957498
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957499
Quantity 96 tests
Datasheet Datasheet

Recommended Lipin 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309703
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309702
Quantity 25 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7398995
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Lipin 1 products

Wei, Seldin, Natarajan, Djemal, Peterson, Wong: "C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis." in: The Journal of biological chemistry, Vol. 288, Issue 15, pp. 10214-29, (2013) (PubMed).

Gong, Traganos, Darzynkiewicz: "Expression of cyclins-B and cyclins-e in individual molt-4 cells and in stimulated human-lymphocytes during their progression through the cell-cycle." in: International journal of oncology, Vol. 3, Issue 6, pp. 1037-42, (2011) (PubMed).

Kim, Kim, Koh, Kim, Lee, Chanda, Park, Min, Lee, Park, Choi: "Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38035-42, (2011) (PubMed).

Valdearcos, Esquinas, Meana, Gil-de-Gómez, Guijas, Balsinde, Balboa: "Subcellular localization and role of lipin-1 in human macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 10, pp. 6004-13, (2011) (PubMed).

Han, Carman: "Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 19, pp. 14628-38, (2010) (PubMed).

Suviolahti, Reue, Cantor, Phan, Gentile, Naukkarinen, Soro-Paavonen, Oksanen, Kaprio, Rissanen, Salomaa, Kontula, Taskinen, Pajukanta, Peltonen: "Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism." in: Human molecular genetics, Vol. 15, Issue 3, pp. 377-86, (2006) (PubMed).

Finck, Gropler, Chen, Leone, Croce, Harris, Lawrence, Kelly: "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway." in: Cell metabolism, Vol. 4, Issue 3, pp. 199-210, (2006) (PubMed).

Han, Wu, Carman: "The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9210-8, (2006) (PubMed).

Péterfy, Phan, Reue: "Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis." in: The Journal of biological chemistry, Vol. 280, Issue 38, pp. 32883-9, (2005) (PubMed).

Huffman, Mothe-Satney, Lawrence: "Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 1047-52, (2002) (PubMed).

Synonyms and alternative names related to Lipin 1

lipin 1 (LPIN1), lipin 1 (lpin1), phosphatidate phosphatase LPIN1 (LOC100539289), lipin 1 (Lpin1), 4631420P06, fld, Kiaa0188, Lipin1, lipin1, LPIN1, mKIAA0188, pap1, PAP1, zgc:194552, zgc:194558

Protein level used designations for Lipin 1

  • lipin 1
  • phosphatidate phosphatase LPIN1-like
  • lipin-1
  • phosphatidate phosphatase LPIN1
  • fatty liver dystrophy protein
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