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LIM Domain Kinase 1 Products

(LIM Domain Kinase 1 (LIMK1))

Categories

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].

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Featured LIM Domain Kinase 1 Categories

LIM Domain Kinase 1 Antibodies

High quality antibodies with extensive validation data.

LIM Domain Kinase 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

LIM Domain Kinase 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LIM Domain Kinase 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (43)
Cat. No. ABIN6255701
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (6)
Cat. No. ABIN1499146
Quantity 100 μL
Datasheet Datasheet
Reactivity Dog, Human, Monkey, Mouse, Rat
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (10)
Cat. No. ABIN1499147
Quantity 100 μL
Datasheet Datasheet

Recommended LIM Domain Kinase 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968294
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648075
Quantity 96 tests
Datasheet Datasheet

Recommended LIM Domain Kinase 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309436
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309434
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5508987
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our LIM Domain Kinase 1 products

Yang, He, Zhang, Chen, Kong, Xie, Jia, Liu, Zhou: "Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain." in: Neuropharmacology, Vol. 125, pp. 284-294, (2018) (PubMed).

Gupta, Yadav, Pavuluri, Morley, Stairs, Dravid: "Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity." in: Neuropharmacology, Vol. 93, pp. 274-84, (2015) (PubMed).

Zhou, Liu, Luo, Zhou, Xia, Chen, Zhou, Zou, Cao, Cao: "MiR-20a inhibits cutaneous squamous cell carcinoma metastasis and proliferation by directly targeting LIMK1." in: Cancer biology & therapy, Vol. 15, Issue 10, pp. 1340-9, (2015) (PubMed).

Park, Agnihotri, Golbourn, Bertrand, Luck, Sabha, Smith, Byron, Zadeh, Croul, Berens, Rutka: "Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway." in: Oncotarget, Vol. 5, Issue 19, pp. 9382-95, (2014) (PubMed).

Zhang, Gan, Zhou: "Immunohistochemical investigation of the correlation between LIM kinase 1 expression and development and progression of human ovarian carcinoma." in: The Journal of international medical research, Vol. 40, Issue 3, pp. 1067-73, (2013) (PubMed).

Li, Ponten, dos Remedios: "The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development." in: Proteomics, Vol. 12, Issue 2, pp. 203-25, (2012) (PubMed).

Jimenez-Mateos, Engel, Merino-Serrais, McKiernan, Tanaka, Mouri, Sano, OTuathaigh, Waddington, Prenter, Delanty, Farrell, OBrien, Conroy, Stallings, DeFelipe, Henshall: "Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects." in: Nature medicine, Vol. 18, Issue 7, pp. 1087-94, (2012) (PubMed).

Guo, Lv, Tian, Hu, Wang, Sui, Jiang, Ruan, Nan: "Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma." in: Carcinogenesis, Vol. 32, Issue 12, pp. 1897-904, (2011) (PubMed).

Li, Ke, Li, Liu, Zhu, Li: "DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1." in: The international journal of biochemistry & cell biology, Vol. 42, Issue 1, pp. 70-9, (2009) (PubMed).

Kobayashi, Nishita, Mishima, Ohashi, Mizuno: "MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration." in: The EMBO journal, Vol. 25, Issue 4, pp. 713-26, (2006) (PubMed).

Synonyms and alternative names related to LIM Domain Kinase 1

LIM domain kinase 1 (LIMK1), LIM domain kinase 1a (limk1a), LIM domain kinase 1 (limk1), LIM domain kinase 1 (CpipJ_CPIJ000717), LIM domain kinase 1 (LOC413152), LIM domain kinase 1 (Limk1), LIM domain kinase 1 L homeolog (limk1.L), LIM-domain containing, protein kinase (Limk1), GB16654, LIMK, LIMK-1, limk1, LIMK1, xlimk1

Protein level used designations for LIM Domain Kinase 1

  • LIM domain kinase 1
  • LIM-kinase1
  • LIM motif-containing protein kinase
  • LIM motif-containing protein kinase 1
  • LIM-domain containing protein kinase 1
  • LIM-domain containing, protein kinase 1
  • LIMK-1
  • chLIMK1
  • KIZ-1
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