LIM Domain Kinase 1 Products
(LIM Domain Kinase 1 (LIMK1))
Categories
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
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Featured LIM Domain Kinase 1 Categories
LIM Domain Kinase 1 Antibodies
High quality antibodies with extensive validation data.
LIM Domain Kinase 1 ELISA Kits
Reliable ELISA kits for a wide range of species.
LIM Domain Kinase 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LIM Domain Kinase 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (43)
Cat. No.
ABIN6255701
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p), FACS
Validations
- (6)
Cat. No.
ABIN1499146
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p), FACS
Validations
- (10)
Cat. No.
ABIN1499147
Quantity
100 μL
Datasheet
Datasheet
Recommended LIM Domain Kinase 1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968294
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648075
Quantity
96 tests
Datasheet
Datasheet
Recommended LIM Domain Kinase 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309436
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309434
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508987
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our LIM Domain Kinase 1 products
: "Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain." in: Neuropharmacology, Vol. 125, pp. 284-294, (2018) (PubMed).: "Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity." in: Neuropharmacology, Vol. 93, pp. 274-84, (2015) (PubMed).
: "MiR-20a inhibits cutaneous squamous cell carcinoma metastasis and proliferation by directly targeting LIMK1." in: Cancer biology & therapy, Vol. 15, Issue 10, pp. 1340-9, (2015) (PubMed).
: "Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway." in: Oncotarget, Vol. 5, Issue 19, pp. 9382-95, (2014) (PubMed).
: "Immunohistochemical investigation of the correlation between LIM kinase 1 expression and development and progression of human ovarian carcinoma." in: The Journal of international medical research, Vol. 40, Issue 3, pp. 1067-73, (2013) (PubMed).
: "The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development." in: Proteomics, Vol. 12, Issue 2, pp. 203-25, (2012) (PubMed).
: "Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects." in: Nature medicine, Vol. 18, Issue 7, pp. 1087-94, (2012) (PubMed).
: "Downregulation of p57 accelerates the growth and invasion of hepatocellular carcinoma." in: Carcinogenesis, Vol. 32, Issue 12, pp. 1897-904, (2011) (PubMed).
: "DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1." in: The international journal of biochemistry & cell biology, Vol. 42, Issue 1, pp. 70-9, (2009) (PubMed).
: "MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration." in: The EMBO journal, Vol. 25, Issue 4, pp. 713-26, (2006) (PubMed).
Synonyms and alternative names related to LIM Domain Kinase 1
LIM domain kinase 1 (LIMK1), LIM domain kinase 1a (limk1a), LIM domain kinase 1 (limk1), LIM domain kinase 1 (CpipJ_CPIJ000717), LIM domain kinase 1 (LOC413152), LIM domain kinase 1 (Limk1), LIM domain kinase 1 L homeolog (limk1.L), LIM-domain containing, protein kinase (Limk1), GB16654, LIMK, LIMK-1, limk1, LIMK1, xlimk1Protein level used designations for LIM Domain Kinase 1
- LIM domain kinase 1
- LIM-kinase1
- LIM motif-containing protein kinase
- LIM motif-containing protein kinase 1
- LIM-domain containing protein kinase 1
- LIM-domain containing, protein kinase 1
- LIMK-1
- chLIMK1
- KIZ-1
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