LIM Domain Binding 3 Products
(LIM Domain Binding 3 (LDB3))
Categories
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified\; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010].
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Featured LIM Domain Binding 3 Categories
LIM Domain Binding 3 Antibodies
High quality antibodies with extensive validation data.
LIM Domain Binding 3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LIM Domain Binding 3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (2)
- (6)
Cat. No.
ABIN524582
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IF
Validations
- (5)
Cat. No.
ABIN7263475
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6143125
Quantity
100 μL
Datasheet
Datasheet
Recommended LIM Domain Binding 3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6205510
Quantity
96 tests
Datasheet
Datasheet
Recommended LIM Domain Binding 3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309259
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3082876
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3130255
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our LIM Domain Binding 3 products
: "Z-disc-associated, alternatively spliced, PDZ motif-containing protein (ZASP) mutations in the actin-binding domain cause disruption of skeletal muscle actin filaments in myofibrillar myopathy." in: The Journal of biological chemistry, Vol. 289, Issue 19, pp. 13615-26, (2014) (PubMed).: "Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole." in: Circulation, Vol. 129, Issue 19, pp. 1924-36, (2014) (PubMed).
: "Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils." in: The Journal of biological chemistry, Vol. 288, Issue 7, pp. 4891-8, (2013) (PubMed).
: "Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy." in: Cardiovascular research, Vol. 83, Issue 1, pp. 80-8, (2009) (PubMed).
: "Mutations in ZASP define a novel form of muscular dystrophy in humans." in: Annals of neurology, Vol. 57, Issue 2, pp. 269-76, (2005) (PubMed).
: "Characterization and in vivo functional analysis of splice variants of cypher." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7360-5, (2003) (PubMed).
Synonyms and alternative names related to LIM Domain Binding 3
LIM domain binding 3 (LDB3), LIM domain binding 3 (Ldb3), LIM domain binding 3b (ldb3b), LIM domain binding 3 S homeolog (ldb3.S), LIM domain binding 3 (ldb3), LIM domain binding 3a (ldb3a), AW742271, CMD1C, CYPHER, cypher, hm:zehn1639, ldb3, LDB3, ldb3l, LDB3Z1, LDB3Z4, LVNC3, MFM4, MGC52706, MGC75668, ORACLE, PDLIM6, RGD1564875, wu:fi31d08, ZASP, zehn1639, zgc:55814Protein level used designations for LIM Domain Binding 3
- LIM domain-binding protein 3
- PDZ and LIM domain 6
- Z-band alternatively spliced PDZ-motif protein
- protein cypher
- PDZ-LIM domain protein
- cypher
- oracle protein
- protein oracle
- LIM domain binding 3
- LIM domain binding 3 like
- LIM-domain binding factor 3, like
- LIM-domain binding factor 3a
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