LILRB4 Products
(Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))
Categories
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
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Featured LILRB4 Categories
LILRB4 Antibodies
High quality antibodies with extensive validation data.
LILRB4 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended LILRB4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6143221
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7440272
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7158277
Quantity
100 μL
Datasheet
Datasheet
Recommended LILRB4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968284
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957469
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975432
Quantity
96 tests
Datasheet
Datasheet
Recommended LILRB4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7275170
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275191
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275159
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our LILRB4 products
: "Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients." in: PLoS ONE, Vol. 9, Issue 12, pp. e115488, (2015) (PubMed).: "Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. ..." in: Nature immunology, Vol. 16, Issue 3, pp. 267-75, (2015) (PubMed).
: "Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 5, pp. 2110-7, (2012) (PubMed).
: "Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells." in: PLoS ONE, Vol. 6, Issue 7, pp. e22504, (2011) (PubMed).
: "DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function." in: Journal of leukocyte biology, Vol. 89, Issue 6, pp. 893-905, (2011) (PubMed).
: "Identification of a new phenotype of tolerogenic human dendritic cells induced by fungal proteases from Aspergillus oryzae." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 7, pp. 3966-76, (2011) (PubMed).
: "Cytokine induced expression of programmed death ligands in human neutrophils." in: Immunology letters, Vol. 129, Issue 2, pp. 100-7, (2010) (PubMed).
: "Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells." in: Clinical and experimental immunology, Vol. 157, Issue 1, pp. 48-59, (2009) (PubMed).
: "Maturation of dendritic cells depends on proteolytic cleavage by cathepsin X." in: Journal of leukocyte biology, Vol. 84, Issue 5, pp. 1306-15, (2008) (PubMed).
: "Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals." in: The Journal of experimental medicine, Vol. 205, Issue 8, pp. 1797-805, (2008) (PubMed).
Synonyms and alternative names related to LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (LILRB4), leukocyte immunoglobulin like receptor B4 (LILRB4), leukocyte immunoglobulin-like receptor, subfamily B, member 4A (Lilrb4a), CD85K, gp49, Gp49b, HM18, ILT-3, ILT3, LIR-5, LIR5Protein level used designations for LILRB4
- leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
- CD85 antigen-like family member K
- immunoglobulin-like transcript 3
- leukocyte immunoglobulin-like receptor 5
- leukocyte immunoglobulin-like receptor subfamily B member 4
- monocyte inhibitory receptor HM18
- glycoprotein 49 B
- mast cell surface glycoprotein Gp49B
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