LIG3 Products
(Ligase III, DNA, ATP-Dependent (LIG3))
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This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Featured LIG3 Categories
LIG3 Antibodies
High quality antibodies with extensive validation data.
LIG3 ELISA Kits
Reliable ELISA kits for a wide range of species.
LIG3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LIG3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN6143207
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN7257088
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC
Validations
- (1)
- (3)
Cat. No.
ABIN2855575
Quantity
100 μL
Datasheet
Datasheet
Recommended LIG3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968293
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1130035
Quantity
96 tests
Datasheet
Datasheet
Recommended LIG3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309403
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309402
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134693
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our LIG3 products
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).: "PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF." in: Cell reports, Vol. 17, Issue 2, pp. 541-555, (2016) (PubMed).
: "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner." in: Cell cycle (Georgetown, Tex.), Vol. 14, Issue 2, pp. 269-76, (2015) (PubMed).
: "DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair." in: Nucleic acids research, Vol. 43, Issue 2, pp. 875-92, (2015) (PubMed).
: "Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair." in: DNA repair, Vol. 16, pp. 44-53, (2014) (PubMed).
: "Age-dependent decline of DNA base excision repair activity in rat cortical neurons." in: Mechanisms of ageing and development, Vol. 133, Issue 4, pp. 186-94, (2012) (PubMed).
: "Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors." in: International journal of radiation oncology, biology, physics, Vol. 79, Issue 2, pp. 540-8, (2011) (PubMed).
: "Arsenicals affect base excision repair by several mechanisms." in: Mutation research, Vol. 715, Issue 1-2, pp. 32-41, (2011) (PubMed).
: "Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy." in: Blood, Vol. 116, Issue 24, pp. 5298-305, (2010) (PubMed).
: "DNA polymerase beta-dependent long patch base excision repair in living cells." in: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).
Synonyms and alternative names related to LIG3
DNA ligase III (orf36), BRCT domain-containing protein (lig3), DNA ligase 3 (LIG3), ligase III, DNA, ATP-dependent (lig3), DNA ligase 3 (Lig3), DNA ligase III (Bm1_22840), ligase III, DNA, ATP-dependent (Lig3), DNA ligase 3 (ANI_1_2644024), DNA ligase 3 (AOR_1_1174154), DNA ligase 3 (LOC100634887), ligase III, DNA, ATP-dependent L homeolog (lig3.L), An02g06890, AO090003000668, D11Wsu78e, DDBDRAFT_0218523, DDBDRAFT_0232266, DDB_0218523, DDB_0232266, LIG2, LIG3, lig3, orf36, wu:fb12c02, wu:fd10b03, wu:fm79b09Protein level used designations for LIG3
- DNA ligase III
- ligase III, DNA, ATP-dependent
- DNA ligase (ATP) 3
- DNA ligase 3
- ligase II, DNA, ATP-dependent
- polydeoxyribonucleotide synthase [ATP] 3
- DNA ligase 3 isoform alpha
- DNA ligase 3-like
- DNA ligase III isoform alpha
- ligase III, DNA, ATP-dependent L homeolog
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