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LGMN Proteins

(Legumain (LGMN))
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
LGMN Protein (AA 18-435) (His tag) LGMN Protein (AA 18-435) (His tag) LGMN Protein (AA 18-435) (His tag) (ABIN7275145)

LGMN Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

LGMN Protein (AA 18-433) (His tag) LGMN Protein (AA 18-433) (His tag) LGMN Protein (AA 18-433) (His tag) (ABIN7275144)

LGMN Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

LGMN Protein (AA 1-433) (GST tag) LGMN Protein (AA 1-433) (GST tag) LGMN Protein (AA 1-433) (GST tag) (ABIN1309356)

LGMN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

LGMN Proteins by Origin

Find LGMN Proteins for a variety of species such as anti-Human LGMN, anti-Mouse LGMN, anti-Canavalia ensiformis LGMN. The species listed below are among those available. Click on a link to go to the corresponding products.

LGMN Proteins by Source

Here you will find LGMN Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

LGMN Proteins by Protein Type

Here you can find LGMN Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

LGMN Proteins by Application

Find LGMN Proteins validated for a specific application such as ELISA, SDS, WB, AbP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

LGMN Proteins by Biological Activity

Find LGMN Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular LGMN Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275145
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7275144
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309356
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7196760
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5623761
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN5623762
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396532
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413253
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2724612
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2724611
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
Cat. No. ABIN7479365
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Yeast
Validations
Cat. No. ABIN7478981
Quantity 100 μg
Datasheet Datasheet
Reactivity Oryza sativa
Source Yeast
Validations
Cat. No. ABIN1678225
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1614055
Quantity 1 mg
Datasheet Datasheet
Reactivity Cynomolgus
Source Yeast
Validations
Cat. No. ABIN1616697
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our LGMN Proteins

Zhao, Hua, Crowley, Ru, Ni, Shaw, Jiao, Ding, Qu, Hung, Huang, Liu, Ye, Ouyang, Cheng, Liu: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." in: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).

Liu, Xiong, Gong, Zhang, Bai, Luo, Li, Wei, Liu, Tan, Xiang: "Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment." in: Nature communications, Vol. 5, pp. 4280, (2014) (PubMed).

Hasegawa, Yamasaki, Fukui: "Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney." in: Biochemical and biophysical research communications, Vol. 453, Issue 3, pp. 631-5, (2014) (PubMed).

Aliases for LGMN Proteins

legumain (LGMN) Proteins
legumain (Lgmn) Proteins
legumain L homeolog (lgmn.L) Proteins
legumain (lgmn) Proteins
delta vacuolar processing enzyme (DELTA-VPE) Proteins
legumain (MBOO_RS07785) Proteins
Legumain (Odosp_3582) Proteins
legumain (LOC569153) Proteins
AEP Proteins
AI746452 Proteins
AU022324 Proteins
cb173 Proteins
cb460 Proteins
DELTA VACUOLAR PROCESSING ENZYME Proteins
delta vacuolar processing enzyme Proteins
DELTAVPE Proteins
lgmn Proteins
LGMN1 Proteins
MGC64351 Proteins
MGC88980 Proteins
PRSC1 Proteins
Prsc1 Proteins
sb:cb173 Proteins
wu:fa98g05 Proteins
wu:fj92g08 Proteins
zgc:76953 Proteins
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