Left-Right Determination Factor Products
(Left-Right Determination Factor (LEFTY-A))
Categories
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010].
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Featured Left-Right Determination Factor Categories
Left-Right Determination Factor Antibodies
High quality antibodies with extensive validation data.
Recommended Left-Right Determination Factor Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IHC, IP, RIA
Validations
- (3)
- (1)
Cat. No.
ABIN103459
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
Cat. No.
ABIN5623568
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
Cat. No.
ABIN1983337
Quantity
100 μg
Datasheet
Datasheet
Recommended Left-Right Determination Factor ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4883592
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6386359
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our Left-Right Determination Factor products
: "Lefty inhibits receptor-regulated Smad phosphorylation induced by the activated transforming growth factor-beta receptor." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21397-404, (2001) (PubMed).: "Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 20, pp. 11376-81, (1999) (PubMed).
: "lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal." in: Cell, Vol. 94, Issue 3, pp. 287-97, (1998) (PubMed).
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